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Magee2 Gene Detail
Summary
  • Symbol
    Magee2
  • Name
    MAGE family member E2
  • Synonyms
    9630059J11Rik, Mage-e2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148316
    NCBI Gene: 272790
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:103898558-103900873 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 46.77 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148316
 protein coding gene ChrX:103898558-103900873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035993
 protein coding gene ChrX:101595808-101598123 (-)
A/J MGP_AJ_G0035974
 protein coding gene ChrX:101441852-101444157 (-)
AKR/J MGP_AKRJ_G0035892
 protein coding gene ChrX:104597910-104600229 (-)
BALB/cJ MGP_BALBcJ_G0035964
 protein coding gene ChrX:100251832-100254147 (-)
C3H/HeJ MGP_C3HHeJ_G0035670
 protein coding gene ChrX:102046967-102049282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036490
 protein coding gene ChrX:104529987-104532302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033318
 protein coding gene ChrX:98995859-98998156 (-)
CAST/EiJ MGP_CASTEiJ_G0034956
 protein coding gene ChrX:86261313-86263614 (-)
CBA/J MGP_CBAJ_G0035645
 protein coding gene ChrX:107823613-107825928 (-)
DBA/2J MGP_DBA2J_G0035799
 protein coding gene ChrX:100714157-100716476 (-)
FVB/NJ MGP_FVBNJ_G0035740
 protein coding gene ChrX:100014543-100016858 (-)
LP/J MGP_LPJ_G0035892
 protein coding gene ChrX:102565159-102567474 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035772
 protein coding gene ChrX:112477335-112479650 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036516
 protein coding gene ChrX:101258854-101261173 (-)
PWK/PhJ MGP_PWKPhJ_G0034654
 protein coding gene ChrX:83800340-83802654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034482
 protein coding gene ChrX:86964819-86967128 (+)
WSB/EiJ MGP_WSBEiJ_G0035096
 protein coding gene ChrX:99957144-99959463 (-)



Homology
more
  • Human Ortholog
    MAGEE2, MAGE family member E2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEE2, MAGE family member E2
  • Synonyms
    HCA3
  • Links
    NCBI Gene ID: 139599
    neXtProt AC: NX_Q8TD90
    UniProt: Q8TD90

  • Chr Location
    Xq13.3; chrX:75782987-75785254 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele exhibit enlarged brain structures with a marked increase in total granular retrosplenial cortex area and in total brain area. In contrast, homozygous females show an opposite but non-significant trend towards reduced brain size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    28
  • cDNA Data
    11
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 272790 NCBI Gene Model | MGI Sequence Detail 2316 C57BL/6J ±  kb
    transcript NM_053206 RefSeq | MGI Sequence Detail 2338 C57BL/6  
    polypeptide NP_444436 RefSeq | MGI Sequence Detail 523 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR002190 MAGE homology domain
      IPR041898 MAGE homology domain, winged helix WH1 motif
      IPR041899 MAGE homology domain, winged helix WH2 motif
      IPR037445 Melanoma-associated antigen
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2148037, MGI:3036244
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 10
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:70396 Chomez P, et al., An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res. 2001 Jul 15;61(14):5544-51
    • Latest
      J:324106 Szpak M, et al., A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice. Mol Biol Evol. 2021 Dec 9;38(12):5655-5663
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory