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Drgx Gene Detail
Summary
  • Symbol
    Drgx
  • Name
    dorsal root ganglia homeobox
  • Synonyms
    Drg11, Prrxl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148204
    NCBI Gene: 107751
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32321364-32371203 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 19.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    326 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148204
 protein coding gene Chr14:32317824-32371203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021148
 protein coding gene Chr14:25853390-25906573 (+)
A/J MGP_AJ_G0021096
 protein coding gene Chr14:24867457-24918901 (+)
AKR/J MGP_AKRJ_G0021073
 protein coding gene Chr14:26024920-26074320 (+)
BALB/cJ MGP_BALBcJ_G0021100
 protein coding gene Chr14:25050287-25100639 (+)
C3H/HeJ MGP_C3HHeJ_G0020883
 protein coding gene Chr14:25897252-25948437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021532
 protein coding gene Chr14:26878721-26931573 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019094
 protein coding gene Chr14:24933676-24985009 (+)
CAST/EiJ MGP_CASTEiJ_G0020408
 protein coding gene Chr14:25702548-25760410 (+)
CBA/J MGP_CBAJ_G0020850
 protein coding gene Chr14:27876450-27938216 (+)
DBA/2J MGP_DBA2J_G0020972
 protein coding gene Chr14:24894859-24944462 (+)
FVB/NJ MGP_FVBNJ_G0020956
 protein coding gene Chr14:24860193-24911106 (+)
LP/J MGP_LPJ_G0021041
 protein coding gene Chr14:26169866-26225871 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020982
 protein coding gene Chr14:27089980-27141765 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021565
 protein coding gene Chr14:25811864-25866255 (+)
PWK/PhJ MGP_PWKPhJ_G0020156
 protein coding gene Chr14:24384636-24434691 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019980
 protein coding gene Chr14:25426898-25486489 (+)
WSB/EiJ MGP_WSBEiJ_G0020463
 protein coding gene Chr14:25874835-25926453 (+)



Homology
more
  • Human Ortholog
    DRGX, dorsal root ganglia homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DRGX, dorsal root ganglia homeobox
  • Synonyms
    DRG11, PRRXL1
  • Links
    NCBI Gene ID: 644168
    neXtProt AC: NX_A6NNA5
    UniProt: A6NNA5

  • Chr Location
    10q11.23; chr10:49364066-49396089 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice had delayed projection of sensory afferent neurons in the dorsal, but not the ventral, spinal cord during embryonic development. This delayed development resulted in abnormal responses to noxious stimuli in adults, but normal locomotion and sensory motor function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    95
  • cDNA Data
    7
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041730 Ensembl Gene Model | MGI Sequence Detail 49840 C57BL/6J ±  kb
    transcript ENSMUST00000186452 Ensembl | MGI Sequence Detail 2371 Not Applicable  
    polypeptide ENSMUSP00000139756 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 7
      Primer pair 6
      Other 5

      Microarray probesets 1
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 36
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:70560 Chen Z, et al., The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
    • Latest
      J:337785 Lowenstein ED, et al., Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Neuron. 2023 May 10;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory