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Slc38a5 Gene Detail
Summary
  • Symbol
    Slc38a5
  • Name
    solute carrier family 38, member 5
  • Synonyms
    C81234, JM24, SN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148066
    NCBI Gene: 209837
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:8137620-8146418 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148066
 protein coding gene ChrX:8137372-8146418 (+)
129S1/SvImJ ENSMUSG00200033982
 protein coding gene ChrX:2838734-2847757 (+)
A/J ENSMUSG00195039163
 protein coding gene ChrX:2861672-2870727 (+)
AKR/J ENSMUSG00220028626
 protein coding gene ChrX:2849461-2858498 (+)
BALB/cJ ENSMUSG00180028482
 protein coding gene ChrX:2859473-2868527 (+)
C3H/HeJ ENSMUSG00175033115
 protein coding gene ChrX:2873361-2882410 (+)
C57BL/6NJ ENSMUSG00215040205
 protein coding gene ChrX:3537174-3546223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032919
 protein coding gene ChrX:2420735-2429662 (+)
CAST/EiJ ENSTCUG00005029244
 protein coding gene ChrX:2808327-2817361 (+)
CBA/J ENSMUSG00210037819
 protein coding gene ChrX:2890231-2899280 (+)
DBA/2J ENSMUSG00185028147
 protein coding gene ChrX:9507359-9516407 (+)
FVB/NJ ENSMUSG00205021035
 protein coding gene ChrX:2884187-2893232 (+)
JF1/MsJ ENSUMUG00000035098
 protein coding gene ChrX:23400708-23409795 (+)
LP/J ENSMUSG00230031100
 protein coding gene ChrX:14027528-14036556 (+)
NOD/ShiLtJ ENSMUSG00190033823
 protein coding gene ChrX:2864218-2873252 (+)
NZO/HlLtJ ENSMUSG00225044441
 protein coding gene ChrX:19293267-19302315 (+)
PWK/PhJ ENSLUMG00010032984
 protein coding gene ChrX:2856595-2865663 (+)
SPRET/EiJ ENSMSPG00010021511
 protein coding gene ChrX:2896042-2905134 (+)
WSB/EiJ ENSIUOG00005029414
 protein coding gene ChrX:15655615-15664655 (-)



Homology
more
  • Human Ortholog
    SLC38A5, solute carrier family 38 member 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC38A5, solute carrier family 38 member 5
  • Synonyms
    JM24, pp7194, SN2, SNAT5
  • Links
    NCBI Gene ID: 92745
    UniProt: Q8WUX1

  • Chr Location
    Xp11.23; chrX:48458537-48470554 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product plays a role in mediating amino-acid-stimulated pancreatic alpha cell proliferation. Under glucagon receptor (Gcgr) inhibition conditions, homozygous KO reduces alpha cell hyperplasia and causes hypoglycemia and increased plasma glucagon and amino acid levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    50
  • cDNA Data
    22
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 209837 NCBI Gene Model | MGI Sequence Detail 8799 C57BL/6J ±  kb
transcript NM_172479 RefSeq | MGI Sequence Detail 1878 C57BL/6  
polypeptide Q3U1J0 UniProt | EBI | MGI Sequence Detail 479 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 22
    Primer pair 5

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 11
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:389151 Sellick K, et al., alpha-cell SLC38A5 supports amino acid-induced alpha-cell proliferation and glucagon secretion. Front Endocrinol (Lausanne). 2026;17:1830329
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory