About   Help   FAQ
Mpig6b Gene Detail
Summary
  • Symbol
    Mpig6b
  • Name
    megakaryocyte and platelet inhibitory receptor G6b
  • Synonyms
    AU023871, G6b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146995
    NCBI Gene: 106722
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35281669-35285160 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.59 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146995
 protein coding gene Chr17:35281669-35285761 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023611
 protein coding gene Chr17:35202504-35207511 (-)
A/J MGP_AJ_G0023571
 protein coding gene Chr17:34036462-34039958 (-)
AKR/J MGP_AKRJ_G0023539
 protein coding gene Chr17:34511047-34514530 (-)
BALB/cJ MGP_BALBcJ_G0023577
 protein coding gene Chr17:34172745-34176221 (-)
C3H/HeJ MGP_C3HHeJ_G0023338
 protein coding gene Chr17:34903830-34907311 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024016
 protein coding gene Chr17:36539453-36542944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021497
 protein coding gene Chr17:31803459-31806898 (-)
CAST/EiJ MGP_CASTEiJ_G0022835
 protein coding gene Chr17:34906477-34909958 (-)
CBA/J MGP_CBAJ_G0023316
 protein coding gene Chr17:38046653-38050129 (-)
DBA/2J MGP_DBA2J_G0023444
 protein coding gene Chr17:33357121-33360599 (-)
FVB/NJ MGP_FVBNJ_G0023411
 protein coding gene Chr17:33193316-33198198 (-)
LP/J MGP_LPJ_G0023521
 protein coding gene Chr17:35528199-35531688 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023433
 protein coding gene Chr17:36983834-36987325 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024061
 protein coding gene Chr17:34730238-34733718 (-)
PWK/PhJ MGP_PWKPhJ_G0022582
 protein coding gene Chr17:32190178-32193780 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022402
 protein coding gene Chr17:32740454-32743933 (-)
WSB/EiJ MGP_WSBEiJ_G0022898
 protein coding gene Chr17:34849298-34852767 (-)



Homology
more
  • Human Ortholog
    MPIG6B, megakaryocyte and platelet inhibitory receptor G6b
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPIG6B, megakaryocyte and platelet inhibitory receptor G6b
  • Synonyms
    C6orf25, G6b, G6b-B, NG31, THAMY
  • Links
    NCBI Gene ID: 80739
    neXtProt AC: NX_O95866
    UniProt: O95866

  • Chr Location
    6p21.33; chr6:31718594-31726714 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit macrothrombocytopenic, increased platelet turnover, enlarged spleen, extramedullary hematopoiesis, myelofibrosis, increased bleeding time, and impaired stimulated platelet adhesion, aggregation and ATP sectretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000073414 Ensembl Gene Model | MGI Sequence Detail 3492 C57BL/6J ±  kb
    transcript ENSMUST00000174190 Ensembl | MGI Sequence Detail 729 Not Applicable  
    polypeptide ENSMUSP00000133377 Ensembl | MGI Sequence Detail 242 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 33
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:281749 Vogtle T, et al., Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. Elife. 2019 Aug 22;8:e46840
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory