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Slc7a4 Gene Detail
Summary
  • Symbol
    Slc7a4
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
  • Synonyms
    MGC:27672
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146512
    NCBI Gene: 224022
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17389882-17394619 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    178 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146512
 protein coding gene Chr16:17389882-17401078 (-)
129S1/SvImJ ENSMUSG00200041981
 protein coding gene Chr16:14386435-14397639 (-)
A/J ENSMUSG00195028323
 protein coding gene Chr16:13943703-13954912 (-)
AKR/J ENSMUSG00220040821
 protein coding gene Chr16:14259978-14271186 (-)
BALB/cJ ENSMUSG00180035994
 protein coding gene Chr16:14184939-14196141 (-)
C3H/HeJ ENSMUSG00175038521
 protein coding gene Chr16:14329963-14341171 (-)
C57BL/6NJ ENSMUSG00215040760
 protein coding gene Chr16:14051091-14062266 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020521
 protein coding gene Chr16:14069565-14074575 (-)
CAST/EiJ ENSTCUG00005045075
 protein coding gene Chr16:14247787-14258994 (-)
CBA/J ENSMUSG00210045845
 protein coding gene Chr16:14346267-14357483 (-)
DBA/2J ENSMUSG00185033044
 protein coding gene Chr16:14292423-14303636 (-)
FVB/NJ ENSMUSG00205034003
 protein coding gene Chr16:14300032-14311236 (-)
JF1/MsJ ENSUMUG00000049860
 protein coding gene Chr16:14374789-14385943 (-)
LP/J ENSMUSG00230039062
 protein coding gene Chr16:16870330-16881536 (-)
NOD/ShiLtJ ENSMUSG00190029547
 protein coding gene Chr16:14432339-14443539 (-)
NZO/HlLtJ ENSMUSG00225031498
 protein coding gene Chr16:20116133-20127341 (-)
PWK/PhJ ENSLUMG00010046297
 protein coding gene Chr16:14257093-14268260 (-)
SPRET/EiJ ENSMSPG00010044593
 protein coding gene Chr16:14277659-14288765 (-)
WSB/EiJ ENSIUOG00005033532
 protein coding gene Chr16:14425650-14436863 (-)



Homology
more
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A4, solute carrier family 7 member 4
  • Synonyms
    CAT-4, CAT4, HCAT3, VH
  • Links
    NCBI Gene ID: 6545
    UniProt: O43246

  • Chr Location
    22q11.21; chr22:21028718-21032933 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    141
  • cDNA Data
    34
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 224022 NCBI Gene Model | MGI Sequence Detail 4738 C57BL/6J ±  kb
transcript NM_001416939 RefSeq | MGI Sequence Detail 3565 C57BL/6  
polypeptide Q8BLQ7 UniProt | EBI | MGI Sequence Detail 635 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 34
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:359574 Eom TY, et al., Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome. Nat Commun. 2024 Dec 5;15(1):10510
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory