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Cip2a Gene Detail
Summary
  • Symbol
    Cip2a
  • Name
    cell proliferation regulating inhibitor of protein phosphatase 2A
  • Synonyms
    C330027C09Rik, Cip2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146335
    NCBI Gene: 224171
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48814548-48840072 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146335
 protein coding gene Chr16:48814524-48840079 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022871
 protein coding gene Chr16:47874760-47900279 (+)
A/J MGP_AJ_G0022837
 protein coding gene Chr16:45768488-45793926 (+)
AKR/J MGP_AKRJ_G0022809
 protein coding gene Chr16:47291163-47316689 (+)
BALB/cJ MGP_BALBcJ_G0022838
 protein coding gene Chr16:45810834-45836421 (+)
C3H/HeJ MGP_C3HHeJ_G0022601
 protein coding gene Chr16:47365620-47391109 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023285
 protein coding gene Chr16:49087813-49113328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020798
 protein coding gene Chr16:45874809-45900416 (+)
CAST/EiJ MGP_CASTEiJ_G0022127
 protein coding gene Chr16:47656283-47685980 (+)
CBA/J MGP_CBAJ_G0022574
 protein coding gene Chr16:50989087-51014556 (+)
DBA/2J MGP_DBA2J_G0022705
 protein coding gene Chr16:45494952-45523536 (+)
FVB/NJ MGP_FVBNJ_G0022681
 protein coding gene Chr16:45377281-45402776 (+)
LP/J MGP_LPJ_G0022773
 protein coding gene Chr16:47629964-47659689 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022699
 protein coding gene Chr16:50737792-50776935 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023300
 protein coding gene Chr16:47305295-47331580 (+)
PWK/PhJ MGP_PWKPhJ_G0021867
 protein coding gene Chr16:45830564-45856380 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021697
 protein coding gene Chr16:47157341-47184524 (+)
WSB/EiJ MGP_WSBEiJ_G0022172
 protein coding gene Chr16:47349037-47374553 (+)



Homology
more
  • Human Ortholog
    CIP2A, cellular inhibitor of PP2A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIP2A, cellular inhibitor of PP2A
  • Synonyms
    KIAA1524, NOCIVA, p90
  • Links
    NCBI Gene ID: 57650
    neXtProt AC: NX_Q8TCG1
    UniProt: Q8TCG1

  • Chr Location
    3q13.13; chr3:108549864-108589644 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele display oligozoospermia, small epididymis and impaired spermatogonial progenitor cell maintenance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    10
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033031 Ensembl Gene Model | MGI Sequence Detail 25525 C57BL/6J ±  kb
    transcript ENSMUST00000048374 Ensembl | MGI Sequence Detail 3974 Not Applicable  
    polypeptide ENSMUSP00000044714 Ensembl | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2146550
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:311352 Zhou Y, et al., Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020 Dec;34(12):16414-16431
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory