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Dock10 Gene Detail
Summary
  • Symbol
    Dock10
  • Name
    dedicator of cytokinesis 10
  • Synonyms
    9330153B10Rik, A630054M16Rik, Jr4, Jr5, mKIAA0694, ZIZ3, Zizimin3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146320
    NCBI Gene: 210293
  • Alliance
    genome feature page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:80478790-80736244 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 41.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7748 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146320
 protein coding gene Chr1:80478785-80736482 (-)
129S1/SvImJ ENSMUSG00200034553
 protein coding gene Chr1:78153719-78408209 (-)
A/J ENSMUSG00195009916
 protein coding gene Chr1:77564277-77816013 (-)
AKR/J ENSMUSG00220010012
 protein coding gene Chr1:77734071-78001361 (-)
BALB/cJ ENSMUSG00180015564
 protein coding gene Chr1:77826730-78084126 (-)
C3H/HeJ ENSMUSG00175017078
 protein coding gene Chr1:77970741-78222426 (-)
C57BL/6NJ ENSMUSG00215015990
 protein coding gene Chr1:77875047-78132430 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014322
 protein coding gene Chr1:73773934-74023163 (-)
CAST/EiJ ENSTCUG00005025306
 protein coding gene Chr1:77525052-77775428 (-)
CBA/J ENSMUSG00210034422
 protein coding gene Chr1:77742957-77995125 (-)
DBA/2J ENSMUSG00185028670
 protein coding gene Chr1:78789033-79041250 (-)
FVB/NJ ENSMUSG00205036576
 protein coding gene Chr1:77308339-77552951 (-)
JF1/MsJ ENSUMUG00000003350
 protein coding gene Chr1:77600440-77857713 (-)
LP/J ENSMUSG00230011906
 protein coding gene Chr1:78726754-78981236 (-)
NOD/ShiLtJ ENSMUSG00190023132
 protein coding gene Chr1:77946578-78198763 (-)
NZO/HlLtJ ENSMUSG00225038762
 protein coding gene Chr1:81966265-82220749 (-)
PWK/PhJ ENSLUMG00010013322
 protein coding gene Chr1:77209421-77470085 (-)
SPRET/EiJ ENSMSPG00010018818
 protein coding gene Chr1:79367409-79621268 (-)
WSB/EiJ ENSIUOG00005012025
 protein coding gene Chr1:77490390-77754687 (-)



Homology
more
  • Human Ortholog
    DOCK10, dedicator of cytokinesis 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK10, dedicator of cytokinesis 10
  • Synonyms
    DRIP2, Nbla10300, ZIZ3
  • Links
    NCBI Gene ID: 55619
    UniProt: Q96BY6

  • Chr Location
    2q36.2; chr2:224765090-225042468 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction of B cell numbers in secondary lymphoid organs. Follicular B cells show membrane CD23 overexpression. Homozygous KO also leads to a thinner spleen marginal zone B cell region and a decreased thymic CD8+ T cell percentage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    37
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038608 Ensembl Gene Model | MGI Sequence Detail 257455 C57BL/6J ±  kb
    transcript ENSMUST00000077946 Ensembl | MGI Sequence Detail 7198 Not Applicable  
    polypeptide ENSMUSP00000077099 Ensembl | MGI Sequence Detail 2187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2441818
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory