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Egflam Gene Detail
Summary
  • Symbol
    Egflam
  • Name
    EGF-like, fibronectin type III and laminin G domains
  • Synonyms
    nectican, pikachurin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146149
    NCBI Gene: 268780
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:7235601-7427876 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 3.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5254 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146149
 protein coding gene Chr15:7235598-7428203 (-)
129S1/SvImJ ENSMUSG00200031985
 protein coding gene Chr15:4211286-4403574 (-)
A/J ENSMUSG00195009760
 protein coding gene Chr15:4128717-4321007 (-)
AKR/J ENSMUSG00220021532
 protein coding gene Chr15:3991263-4177072 (-)
BALB/cJ ENSMUSG00180033586
 protein coding gene Chr15:4105834-4298129 (-)
C3H/HeJ ENSMUSG00175028213
 protein coding gene Chr15:4265942-4458208 (-)
C57BL/6NJ ENSMUSG00215016519
 protein coding gene Chr15:4119168-4311440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019645
 protein coding gene Chr15:3747215-3924988 (-)
CAST/EiJ ENSTCUG00005024803
 protein coding gene Chr15:4176932-4355215 (-)
CBA/J ENSMUSG00210025026
 protein coding gene Chr15:4250904-4443186 (-)
DBA/2J ENSMUSG00185031375
 protein coding gene Chr15:4203998-4396294 (-)
FVB/NJ ENSMUSG00205023543
 protein coding gene Chr15:4119796-4307429 (-)
JF1/MsJ ENSUMUG00000020653
 protein coding gene Chr15:4258655-4438057 (-)
LP/J ENSMUSG00230017297
 protein coding gene Chr15:7704474-7896733 (-)
NOD/ShiLtJ ENSMUSG00190009482
 protein coding gene Chr15:4186654-4378933 (-)
NZO/HlLtJ ENSMUSG00225034619
 protein coding gene Chr15:7956387-8148688 (-)
PWK/PhJ ENSLUMG00010033409
 protein coding gene Chr15:4278496-4457870 (-)
SPRET/EiJ ENSMSPG00010031239
 protein coding gene Chr15:4296082-4479011 (-)
WSB/EiJ ENSIUOG00005028133
 protein coding gene Chr15:4117376-4303118 (-)



Homology
more
  • Human Ortholog
    EGFLAM, EGF like, fibronectin type III and laminin G domains
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGFLAM, EGF like, fibronectin type III and laminin G domains
  • Synonyms
    AGRINL, AGRNL, PIKA
  • Links
    NCBI Gene ID: 133584
    UniProt: Q63HQ2

  • Chr Location
    5p13.2-p13.1; chr5:38258409-38465480 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are viable and fertile under normal conditions. They exhibit abnormal photoreceptor ribbon synapses, resulting in alteration in synaptic signal transmission and visual function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    5
  • cDNA Data
    44
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042961 Ensembl Gene Model | MGI Sequence Detail 192276 C57BL/6J ±  kb
    transcript ENSMUST00000096494 Ensembl | MGI Sequence Detail 4391 Not Applicable  
    polypeptide ENSMUSP00000094238 Ensembl | MGI Sequence Detail 1017 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 44
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:390147 Tu HY, et al., Transcription co-repressors Panky and Panky-like modulate ganglioside levels and are essential for retinal cone photoreceptor structure and survival. J Neurosci. 2026 Jul 16;:e0052262026
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory