Amigo2 MGI Mouse Gene Detail - MGI:2145995 - adhesion molecule with Ig like domain 2

Symbol

Amigo2
Name

adhesion molecule with Ig like domain 2

Feature Type

protein coding gene
IDs

MGI:2145995
NCBI Gene: 105827
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:97142006-97145168 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 52.91 cM
Mapping Data

2 experiments

SNPs within 2kb

106 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145995	protein coding gene	Chr15:97141955-97145168 (-)
129S1/SvImJ	ENSMUSG00200050729	protein coding gene	Chr15:94337039-94340201 (-)
A/J	ENSMUSG00195037254	protein coding gene	Chr15:94178211-94181373 (-)
AKR/J	ENSMUSG00220042161	protein coding gene	Chr15:94188369-94191532 (-)
BALB/cJ	ENSMUSG00180042913	protein coding gene	Chr15:94115261-94118423 (-)
C3H/HeJ	ENSMUSG00175032246	protein coding gene	Chr15:94358465-94361627 (-)
C57BL/6NJ	ENSMUSG00215050633	protein coding gene	Chr15:94178205-94181367 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020210	protein coding gene	Chr15:90953789-90957009 (-)
CAST/EiJ	ENSTCUG00005042302	protein coding gene	Chr15:93640503-93643666 (-)
CBA/J	ENSMUSG00210025243	protein coding gene	Chr15:94148165-94151328 (-)
DBA/2J	ENSMUSG00185033235	protein coding gene	Chr15:94198511-94201674 (-)
FVB/NJ	ENSMUSG00205027961	protein coding gene	Chr15:93918463-93921625 (-)
JF1/MsJ	ENSUMUG00000026555	protein coding gene	Chr15:93699132-93702294 (-)
LP/J	ENSMUSG00230037589	protein coding gene	Chr15:97516705-97519867 (-)
NOD/ShiLtJ	ENSMUSG00190040258	protein coding gene	Chr15:94196159-94199321 (-)
NZO/HlLtJ	ENSMUSG00225041564	protein coding gene	Chr15:97818750-97821914 (-)
PWK/PhJ	ENSLUMG00010036958	protein coding gene	Chr15:93841675-93844837 (-)
SPRET/EiJ	ENSMSPG00010034377	protein coding gene	Chr15:95665655-95668823 (-)
WSB/EiJ	ENSIUOG00005028706	protein coding gene	Chr15:94259521-94262688 (-)

Human Ortholog

AMIGO2, adhesion molecule with Ig like domain 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMIGO2, adhesion molecule with Ig like domain 2
Synonyms

ALI1, AMIGO-2, DEGA
Links

HGNC:24073

NCBI Gene ID: 347902

UniProt: Q86SJ2
Chr Location

12q13.11; chr12:47075707-47080902 (-) GRCh38

MGI Vertebrate Homology

Amigo2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: AMIGO2
Gene Tree

Amigo2

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

7
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Amigo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit starburst amacrine cell and rod bipolar cell dendrite arbor expansion and enhanced direction selectivity of direction-selective ganglion cell responses to starburst amacrine cell signals.

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All GO Annotations

15
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

669
Tissues

42
cDNA Data

9
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMIGO2

Xenbase amigo2

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All Sequences

44
RefSeq

6
UniProt

2
CCDS

CCDS27780.1

Ensembl

ENSMUSG00000048218 (Evidence)
NCBI Gene

105827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000048218	Ensembl Gene Model \| MGI Sequence Detail	3163	C57BL/6J	± kb
transcript	ENSMUST00000229890	Ensembl \| MGI Sequence Detail	2998	Not Applicable
polypeptide	ENSMUSP00000155019	Ensembl \| MGI Sequence Detail	519	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003992 amphoterin-induced protein 2

(term hierarchy)
InterPro Domains

IPR031283 Amphoterin-induced protein

IPR000483 Cysteine-rich flanking region, C-terminal

IPR003599 Immunoglobulin domain subtype

IPR013151 Immunoglobulin-like beta-sandwich domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q80ZD9 10 sites, 2 N-linked glycans (2 sites)

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All nucleic 13

cDNA 9

Primer pair 2

Other 2

Microarray probesets 3

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MGI:2146206

Summaries

All 67

Developmental Gene Expression 10

Diseases 1

Gene Ontology 5

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Amigo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136110	Chr15:97145187-97145196 (-)	-24 bp
Tssr136109	Chr15:97145123-97145138 (-)	37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24