Dip2b MGI Mouse Gene Detail - MGI:2145977 - disco interacting protein 2 homolog B

Symbol

Dip2b
Name

disco interacting protein 2 homolog B
Synonyms

mKIAA1463

Feature Type

protein coding gene
IDs

MGI:2145977
NCBI Gene: 239667
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr15:99936545-100117354 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.14 cM
Mapping Data

2 experiments

SNPs within 2kb

4155 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145977	protein coding gene	Chr15:99935119-100117355 (+)
129S1/SvImJ	ENSMUSG00200048065	protein coding gene	Chr15:97139485-97323541 (+)
A/J	ENSMUSG00195037444	protein coding gene	Chr15:97014756-97200721 (+)
AKR/J	ENSMUSG00220044630	protein coding gene	Chr15:97013094-97193921 (+)
BALB/cJ	ENSMUSG00180036958	protein coding gene	Chr15:96915409-97099415 (+)
C3H/HeJ	ENSMUSG00175039337	protein coding gene	Chr15:97194760-97380722 (+)
C57BL/6NJ	ENSMUSG00215047749	protein coding gene	Chr15:96974964-97155771 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020282	protein coding gene	Chr15:93739336-93925995 (+)
CAST/EiJ	ENSTCUG00005046506	protein coding gene	Chr15:96447545-96634192 (+)
CBA/J	ENSMUSG00210026947	protein coding gene	Chr15:96972298-97156287 (+)
DBA/2J	ENSMUSG00185036226	protein coding gene	Chr15:97019476-97200287 (+)
FVB/NJ	ENSMUSG00205032451	protein coding gene	Chr15:96723968-96904788 (+)
JF1/MsJ	ENSUMUG00000051502	protein coding gene	Chr15:96471178-96651277 (+)
LP/J	ENSMUSG00230038953	protein coding gene	Chr15:100362849-100546894 (+)
NOD/ShiLtJ	ENSMUSG00190045588	protein coding gene	Chr15:96994872-97175687 (+)
NZO/HlLtJ	ENSMUSG00225043025	protein coding gene	Chr15:100611845-100792653 (+)
PWK/PhJ	ENSLUMG00010046245	protein coding gene	Chr15:96694340-96887367 (+)
SPRET/EiJ	ENSMSPG00010047331	protein coding gene	Chr15:98495164-98677844 (+)
WSB/EiJ	ENSIUOG00005032341	protein coding gene	Chr15:97100079-97286133 (+)

Human Ortholog

DIP2B, DIP2 acetate--CoA ligase B (putative)

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DIP2B, DIP2 acetate--CoA ligase B (putative)
Links

HGNC:29284

NCBI Gene ID: 57609

UniProt: Q9P265
Chr Location

12q13.12; chr12:50504962-50748657 (+) GRCh38

MGI Vertebrate Homology

Dip2b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DIP2B
Gene Tree

Dip2b

Diseases

1 with human DIP2B associations

				Human Disease	Mouse Models
				autosomal dominant intellectual developmental disorder type FRA12A IDs autosomal dominant intellectual developmental disorder type FRA12A DOID:0061049 OMIM:136630

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

82
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Dip2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

137 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

675
Tissues

52
cDNA Data

96
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dip2b

ZFIN dip2ba

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All Sequences

61
RefSeq

14
UniProt

3
CCDS

CCDS27831.1, CCDS49731.1

Ensembl

ENSMUSG00000023026 (Evidence)
NCBI Gene

239667

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023026	Ensembl Gene Model \| MGI Sequence Detail	180810	C57BL/6J	± kb
transcript	ENSMUST00000100203	Ensembl \| MGI Sequence Detail	8914	Not Applicable
polypeptide	ENSMUSP00000097777	Ensembl \| MGI Sequence Detail	1574	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006484 disco-interacting protein 2 homolog B

(term hierarchy)
InterPro Domains

IPR025110 AMP-binding enzyme, C-terminal domain

IPR045851 AMP-binding enzyme domain superfamily

IPR000873 AMP-dependent synthetase/ligase domain

IPR042099 ANL, N-terminal domain

IPR037337 Dip2-like domain

IPR010506 DMAP1-binding domain
GlyGen

Q3UH60 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 97

cDNA 96

Primer pair 1

Antibodies 2

Microarray probesets 3

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MGI:2146097

Summaries

All 64

Developmental Gene Expression 5

Diseases 1

Gene Ontology 4

Phenotypes 35
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Dip2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133080	Chr15:99936516-99936550 (+)	-12 bp
Tssr133081	Chr15:99936555-99936602 (+)	34 bp
Tssr133082	Chr15:99936628-99936689 (+)	114 bp
Tssr133083	Chr15:99958126-99958139 (+)	21,588 bp
Tssr4715	Chr15:99961489-99961495 (+)	24,947 bp
Tssr133084	Chr15:99965382-99965394 (+)	28,843 bp
Tssr133085	Chr15:99972985-99973003 (+)	36,449 bp
Tssr4716	Chr15:99982092-99982129 (+)	45,566 bp
Tssr133086	Chr15:100052050-100052095 (+)	115,528 bp
Tssr133087	Chr15:100052260-100052292 (+)	115,731 bp
Tssr133088	Chr15:100054855-100054860 (+)	118,313 bp
Tssr133089	Chr15:100079318-100079329 (+)	142,779 bp
Tssr133090	Chr15:100080154-100080195 (+)	143,630 bp
Tssr133091	Chr15:100096520-100096535 (+)	159,983 bp
Tssr133092	Chr15:100097161-100097177 (+)	160,624 bp
Tssr133093	Chr15:100099981-100099988 (+)	163,440 bp
Tssr133094	Chr15:100115078-100115082 (+)	178,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24