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Akr1c18 Gene Detail
Summary
  • Symbol
    Akr1c18
  • Name
    aldo-keto reductase family 1, member C18
  • Synonyms
    20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145420
    NCBI Gene: 105349
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:4182614-4200645 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 2.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    464 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145420
 protein coding gene Chr13:4182614-4200653 (-)
129S1/SvImJ ENSMUSG00200005691
 protein coding gene Chr13:1354332-1372343 (-)
A/J ENSMUSG00195012029
 protein coding gene Chr13:762526-780535 (-)
AKR/J ENSMUSG00220012877
 protein coding gene Chr13:1053006-1071033 (-)
BALB/cJ ENSMUSG00180008950
 protein coding gene Chr13:1174693-1192702 (-)
C3H/HeJ ENSMUSG00175007742
 protein coding gene Chr13:1204618-1222655 (-)
C57BL/6NJ ENSMUSG00215010997
 protein coding gene Chr13:1424432-1442477 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018201
 protein coding gene Chr13:613642-631746 (-)
CAST/EiJ ENSTCUG00005023588
 protein coding gene Chr13:1427953-1445905 (-)
CBA/J ENSMUSG00210022729
 protein coding gene Chr13:743303-761348 (-)
DBA/2J ENSMUSG00185023938
 protein coding gene Chr13:1431064-1449107 (-)
FVB/NJ ENSMUSG00205021116
 protein coding gene Chr13:1176377-1194386 (-)
JF1/MsJ ENSUMUG00000006872
 protein coding gene Chr13:1428465-1446407 (-)
LP/J ENSMUSG00230006533
 protein coding gene Chr13:10900881-10918819 (-)
NOD/ShiLtJ ENSMUSG00190012317
 protein coding gene Chr13:890239-908256 (-)
NZO/HlLtJ ENSMUSG00225033764
 protein coding gene Chr13:4788563-4806503 (-)
PWK/PhJ ENSLUMG00010016655
 protein coding gene Chr13:808736-826636 (-)
SPRET/EiJ ENSMSPG00010021203
 protein coding gene Chr13:845132-863200 (-)
WSB/EiJ ENSIUOG00005019658
 protein coding gene Chr13:785236-803255 (-)



Homology
more
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1C1, aldo-keto reductase family 1 member C1
  • Synonyms
    20-ALPHA-HSD, 2-ALPHA-HSD, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB
  • Links
    NCBI Gene ID: 1645
    UniProt: Q04828

  • Chr Location
    10p15.1; chr10:4963253-4983283 (+)  GRCh38
  • Human Ortholog
    AKR1C2, aldo-keto reductase family 1 member C2
  • Synonyms
    AKR1C-pseudo, BABP, DD, DD-2, DD2, DD/BABP, DDH2, HAKRD, HBAB, MCDR2, SRXY8, TDD
  • Links
    NCBI Gene ID: 1646
    UniProt: P52895

  • Chr Location
    10p15.1; chr10:4987775-5018031 (-)  GRCh38
  • Human Ortholog
    AKR1C3, aldo-keto reductase family 1 member C3
  • Synonyms
    DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, PGFS
  • Links
    NCBI Gene ID: 8644
    UniProt: P42330

  • Chr Location
    10p15.1; chr10:5035354-5107686 (+)  GRCh38
  • Human Ortholog
    AKR1C4, aldo-keto reductase family 1 member C4
  • Synonyms
    3-alpha-HSD, C11, CDR, CHDR, DD-4, DD4, HAKRA
  • Links
    NCBI Gene ID: 1109
    UniProt: P17516

  • Chr Location
    10p15.1; chr10:5195462-5220608 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human AKR1C2,AKR1C3,AKR1C4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene display prolonged pregnancies and decreased number of pups. Some cannot induce parturition while others are able to give birth but show a prolonged estrous cycle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    113
  • cDNA Data
    18
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105349 NCBI Gene Model | MGI Sequence Detail 18032 C57BL/6J ±  kb
    transcript NM_134066 RefSeq | MGI Sequence Detail 1199 C57BL/6  
    polypeptide Q8K023 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 4
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 18
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:82195 Vergnes L, et al., A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res. 2003 Mar;44(3):503-11
    • Latest
      J:349748 Shi T, et al., Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F(2alpha) (PGF(2alpha)) levels. Biochem Pharmacol. 2024 Jul;225:116309
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory