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Alkbh5 Gene Detail
Summary
  • Symbol
    Alkbh5
  • Name
    alkB homolog 5, RNA demethylase
  • Synonyms
    Abh5, Ofoxd
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144489
    NCBI Gene: 268420
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60428509-60449338 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144489
 protein coding gene Chr11:60427207-60449338 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018420
 protein coding gene Chr11:60422550-60444570 (+)
A/J MGP_AJ_G0018389
 protein coding gene Chr11:58126273-58148582 (+)
AKR/J MGP_AKRJ_G0018359
 protein coding gene Chr11:60073497-60098505 (+)
BALB/cJ MGP_BALBcJ_G0018360
 protein coding gene Chr11:58482533-58504840 (+)
C3H/HeJ MGP_C3HHeJ_G0018173
 protein coding gene Chr11:59944077-59967214 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018812
 protein coding gene Chr11:62331083-62353255 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016458
 protein coding gene Chr11:55363585-55385008 (+)
CAST/EiJ MGP_CASTEiJ_G0017730
 protein coding gene Chr11:60085379-60107287 (+)
CBA/J MGP_CBAJ_G0018147
 protein coding gene Chr11:65067149-65089471 (+)
DBA/2J MGP_DBA2J_G0018256
 protein coding gene Chr11:57781341-57803447 (+)
FVB/NJ MGP_FVBNJ_G0018247
 protein coding gene Chr11:57462082-57483986 (+)
LP/J MGP_LPJ_G0018329
 protein coding gene Chr11:61026349-61049164 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018271
 protein coding gene Chr11:66114424-66136556 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018853
 protein coding gene Chr11:60095940-60117832 (+)
PWK/PhJ MGP_PWKPhJ_G0017501
 protein coding gene Chr11:58391323-58414076 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017293
 protein coding gene Chr11:59895591-59917673 (+)
WSB/EiJ MGP_WSBEiJ_G0017781
 protein coding gene Chr11:59778913-59802870 (+)



Homology
more
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH5, alkB homolog 5, RNA demethylase
  • Synonyms
    ABH5, OFOXD, OFOXD1
  • Links
    NCBI Gene ID: 54890
    neXtProt AC: NX_Q6P6C2
    UniProt: Q6P6C2

  • Chr Location
    17p11.2; chr17:18183078-18209954 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    4
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 268420 NCBI Gene Model | MGI Sequence Detail 20830 C57BL/6J ±  kb
    transcript NM_172943 RefSeq | MGI Sequence Detail 6025 Not Specified  
    polypeptide Q3TSG4 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 13
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144515
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Diseases 2
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346173 Zhuang T, et al., ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice. Nat Commun. 2024 Mar 5;15(1):1995
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory