About   Help   FAQ
Pnpo Gene Detail
Summary
  • Symbol
    Pnpo
  • Name
    pyridoxine 5'-phosphate oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144151
    NCBI Gene: 103711
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96828651-96834812 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144151
 protein coding gene Chr11:96828642-96834845 (-)
129S1/SvImJ ENSMUSG00200052934
 protein coding gene Chr11:94075153-94081553 (-)
A/J ENSMUSG00195051235
 protein coding gene Chr11:93792659-93799041 (-)
AKR/J ENSMUSG00220045094
 protein coding gene Chr11:94051823-94058214 (-)
BALB/cJ ENSMUSG00180045671
 protein coding gene Chr11:94057822-94064215 (-)
C3H/HeJ ENSMUSG00175047509
 protein coding gene Chr11:94055223-94061621 (-)
C57BL/6NJ ENSMUSG00215050972
 protein coding gene Chr11:93646144-93652544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017041
 protein coding gene Chr11:92708457-92714640 (-)
CAST/EiJ ENSTCUG00005049712
 protein coding gene Chr11:93505456-93511664 (-)
CBA/J ENSMUSG00210052890
 protein coding gene Chr11:93754898-93761289 (-)
DBA/2J ENSMUSG00185044009
 protein coding gene Chr11:94105141-94111537 (-)
FVB/NJ ENSMUSG00205038754
 protein coding gene Chr11:93960037-93966435 (-)
JF1/MsJ ENSUMUG00000033531
 protein coding gene Chr11:94408002-94414399 (-)
LP/J ENSMUSG00230048675
 protein coding gene Chr11:95158150-95164546 (-)
NOD/ShiLtJ ENSMUSG00190049808
 protein coding gene Chr11:94151366-94157811 (-)
NZO/HlLtJ ENSMUSG00225049252
 protein coding gene Chr11:97213370-97219764 (-)
PWK/PhJ ENSLUMG00010042257
 protein coding gene Chr11:93959970-93966338 (-)
SPRET/EiJ ENSMSPG00010046369
 protein coding gene Chr11:94458577-94464994 (-)
WSB/EiJ ENSIUOG00005047499
 protein coding gene Chr11:93905818-93912212 (-)



Homology
more
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNPO, pyridoxamine 5'-phosphate oxidase
  • Synonyms
    HEL-S-302, PDXPO
  • Links
    NCBI Gene ID: 55163
    UniProt: Q9NVS9

  • Chr Location
    17q21.32; chr17:47941506-47949308 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PNPO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    96
  • cDNA Data
    132
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018659 Ensembl Gene Model | MGI Sequence Detail 6162 C57BL/6J ±  kb
transcript ENSMUST00000018803 Ensembl | MGI Sequence Detail 1994 Not Applicable  
polypeptide ENSMUSP00000018803 Ensembl | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 134
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:336444 Ngo EO, et al., Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in neoplastic cells: isolation, characterization, and expression of PNPO cDNA. Biochemistry. 1998 May 26;37(21):7741-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory