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Zc3h10 Gene Detail
Summary
  • Symbol
    Zc3h10
  • Name
    zinc finger CCCH type containing 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143670
    NCBI Gene: 103284
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128379429-128383877 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143670
 protein coding gene Chr10:128377832-128383877 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017870
 protein coding gene Chr10:132294023-132299838 (-)
A/J MGP_AJ_G0017845
 protein coding gene Chr10:126978556-126984370 (-)
AKR/J MGP_AKRJ_G0017808
 protein coding gene Chr10:130697622-130703468 (-)
BALB/cJ MGP_BALBcJ_G0017809
 protein coding gene Chr10:127355393-127361207 (-)
C3H/HeJ MGP_C3HHeJ_G0017632
 protein coding gene Chr10:130857577-130863391 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018264
 protein coding gene Chr10:136775103-136780916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015942
 protein coding gene Chr10:120903940-120909751 (-)
CAST/EiJ MGP_CASTEiJ_G0017193
 protein coding gene Chr10:131574803-131580619 (-)
CBA/J MGP_CBAJ_G0017602
 protein coding gene Chr10:142337483-142343298 (-)
DBA/2J MGP_DBA2J_G0017708
 protein coding gene Chr10:126038768-126044575 (-)
FVB/NJ MGP_FVBNJ_G0017703
 protein coding gene Chr10:124961633-124967446 (-)
LP/J MGP_LPJ_G0017782
 protein coding gene Chr10:132877806-132883618 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017731
 protein coding gene Chr10:144916988-144922805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018304
 protein coding gene Chr10:130801571-130807385 (-)
PWK/PhJ MGP_PWKPhJ_G0016978
 protein coding gene Chr10:126297439-126303416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016767
 protein coding gene Chr10:129914383-129920204 (-)
WSB/EiJ MGP_WSBEiJ_G0017252
 protein coding gene Chr10:131018927-131024741 (-)



Homology
more
  • Human Ortholog
    ZC3H10, zinc finger CCCH-type containing 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZC3H10, zinc finger CCCH-type containing 10
  • Synonyms
    ZC3HDC10
  • Links
    NCBI Gene ID: 84872
    neXtProt AC: NX_Q96K80
    UniProt: Q96K80

  • Chr Location
    12q13.2; chr12:56118260-56127514 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with loss of expression in adipose tissue display impaired adaptive thermogenesis, increased body weight, impaired glucose tolerance, and impaired insulin sensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    8
  • cDNA Data
    51
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103284 NCBI Gene Model | MGI Sequence Detail 4449 C57BL/6J ±  kb
    transcript NM_134003 RefSeq | MGI Sequence Detail 2096 C57BL/6  
    polypeptide Q8R205 UniProt | EBI | MGI Sequence Detail 435 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:310885 Audano M, et al., Zc3h10 regulates adipogenesis by controlling translation and F-actin/mitochondria interaction. J Cell Biol. 2021 Mar 1;220(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory