About   Help   FAQ
Lars2 Gene Detail
Summary
  • Symbol
    Lars2
  • Name
    leucyl-tRNA synthetase, mitochondrial
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142973
    NCBI Gene: 102436
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:123196001-123291731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 73.92 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    735 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142973
protein coding gene Chr9:123195992-123291731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035476
protein coding gene Chr9:126404923-126508878 (+)
A/J MGP_AJ_G0035457
protein coding gene Chr9:121571107-121670200 (+)
AKR/J MGP_AKRJ_G0035390
protein coding gene Chr9:124829610-124926941 (+)
BALB/cJ MGP_BALBcJ_G0035453
protein coding gene Chr9:121492645-121603288 (+)
C3H/HeJ MGP_C3HHeJ_G0035160
protein coding gene Chr9:125276697-125376495 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035976
protein coding gene Chr9:129905513-130007288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032858
protein coding gene Chr9:118699706-118793433 (+)
CAST/EiJ MGP_CASTEiJ_G0034465
protein coding gene Chr9:125309954-125412284 (+)
CBA/J MGP_CBAJ_G0035128
protein coding gene Chr9:134617277-134740421 (+)
DBA/2J MGP_DBA2J_G0035287
protein coding gene Chr9:121019159-121115391 (+)
FVB/NJ MGP_FVBNJ_G0035234
protein coding gene Chr9:119924645-120021138 (+)
LP/J MGP_LPJ_G0035366
protein coding gene Chr9:126746149-126845773 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035275
protein coding gene Chr9:135454863-135553853 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035995
protein coding gene Chr9:125295703-125390887 (+)
PWK/PhJ MGP_PWKPhJ_G0034169
protein coding gene Chr9:121465619-121565517 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034006
protein coding gene Chr9:125403932-125510708 (+)
WSB/EiJ MGP_WSBEiJ_G0034585
protein coding gene Chr9:125139978-125235117 (+)



Homology
more
  • Human Ortholog
    LARS2, leucyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LARS2, leucyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    HLASA, LEURS, mtLeuRS, PRLTS4
  • Links
    NCBI Gene ID: 23395
    neXtProt AC: NX_Q15031
    UniProt: Q15031

  • Chr Location
    3p21.31; chr3:45388561-45554726 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human LARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 102436 NCBI Gene Model | MGI Sequence Detail 95731 C57BL/6J ±  kb
transcript NM_001348167 RefSeq | MGI Sequence Detail 4219 ZRU/MplStud  
polypeptide Q8VDC0 UniProt | EBI | MGI Sequence Detail 902 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000032134 leucine--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR002300 Aminoacyl-tRNA synthetase, class Ia
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR002302 Leucine-tRNA ligase
    IPR025709 Leucyl-tRNA synthetase, editing domain
    IPR015413 Methionyl/Leucyl tRNA synthetase
    IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Molecular
Reagents
less
  • All nucleic 52
    cDNA 50
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:80594 Kiss H, et al., Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Mamm Genome. 2002 Nov;13(11):646-55
  • Latest
    J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory