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Cmtm4 Gene Detail
Summary
  • Symbol
    Cmtm4
  • Name
    CKLF-like MARVEL transmembrane domain containing 4
  • Synonyms
    Cklfsf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142888
    NCBI Gene: 97487
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:105074823-105122439 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142888
 protein coding gene Chr8:105074823-105122439 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034009
 protein coding gene Chr8:106479497-106529179 (-)
A/J MGP_AJ_G0033990
 protein coding gene Chr8:102254447-102303905 (-)
AKR/J MGP_AKRJ_G0033916
 protein coding gene Chr8:105224796-105275378 (-)
BALB/cJ MGP_BALBcJ_G0033983
 protein coding gene Chr8:102478641-102527505 (-)
C3H/HeJ MGP_C3HHeJ_G0033695
 protein coding gene Chr8:105925784-105977059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034503
 protein coding gene Chr8:110384108-110442949 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031446
 protein coding gene Chr8:95543597-95591683 (-)
CAST/EiJ MGP_CASTEiJ_G0033022
 protein coding gene Chr8:105476201-105529089 (-)
CBA/J MGP_CBAJ_G0033669
 protein coding gene Chr8:114040318-114097919 (-)
DBA/2J MGP_DBA2J_G0033823
 protein coding gene Chr8:101621052-101670086 (-)
FVB/NJ MGP_FVBNJ_G0033770
 protein coding gene Chr8:100554068-100605356 (-)
LP/J MGP_LPJ_G0033914
 protein coding gene Chr8:106667535-106723576 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033812
 protein coding gene Chr8:117225715-117277064 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034521
 protein coding gene Chr8:105167272-105217578 (-)
PWK/PhJ MGP_PWKPhJ_G0032724
 protein coding gene Chr8:101026916-101079559 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032563
 protein coding gene Chr8:104001286-104050861 (-)
WSB/EiJ MGP_WSBEiJ_G0033137
 protein coding gene Chr8:105851974-105904986 (-)



Homology
more
  • Human Ortholog
    CMTM4, CKLF like MARVEL transmembrane domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CMTM4, CKLF like MARVEL transmembrane domain containing 4
  • Synonyms
    CKLFSF4
  • Links
    NCBI Gene ID: 146223
    neXtProt AC: NX_Q8IZR5
    UniProt: Q8IZR5

  • Chr Location
    16q21-q22.1; chr16:66598178-66696743 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show decreased daily sperm production and progressive sperm motility, abnormal spermatozoa with backward-curved heads or bent midpieces, and male subfertility. Mice homozygous for a different knock-out allele show a decreased inflammatory response to IL-17A administration and decreased susceptibility to experimental psoriasis but not to experimental autoimmune encephalomyelitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    9
  • cDNA Data
    5
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 97487 NCBI Gene Model | MGI Sequence Detail 47617 C57BL/6J ±  kb
    transcript NM_153582 RefSeq | MGI Sequence Detail 7734 C57BL/6  
    polypeptide Q8CJ61 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:84235 Han W, et al., Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Genomics. 2003 Jun;81(6):609-17
    • Latest
      J:333836 Knizkova D, et al., CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. Nat Immunol. 2022 Nov;23(11):1644-1652
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory