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Ano1 Gene Detail
Summary
  • Symbol
    Ano1
  • Name
    anoctamin 1, calcium activated chloride channel
  • Synonyms
    Tmem16a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142149
    NCBI Gene: 101772
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:144142286-144305711 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 88.85 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1287 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142149
 protein coding gene Chr7:144142286-144305762 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033290
 protein coding gene Chr7:149955151-150128080 (-)
A/J MGP_AJ_G0033273
 protein coding gene Chr7:145596449-145760191 (-)
AKR/J MGP_AKRJ_G0033204
 protein coding gene Chr7:149700839-149866261 (-)
BALB/cJ MGP_BALBcJ_G0033273
 protein coding gene Chr7:145378614-145542031 (-)
C3H/HeJ MGP_C3HHeJ_G0032987
 protein coding gene Chr7:149463144-149627245 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033783
 protein coding gene Chr7:155371323-155538544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030756
 protein coding gene Chr7:146757506-146917598 (-)
CAST/EiJ MGP_CASTEiJ_G0032310
 protein coding gene Chr7:141773340-141947976 (-)
CBA/J MGP_CBAJ_G0032960
 protein coding gene Chr7:160662056-160834525 (-)
DBA/2J MGP_DBA2J_G0033114
 protein coding gene Chr7:143576813-143738509 (-)
FVB/NJ MGP_FVBNJ_G0033062
 protein coding gene Chr7:143514585-143679474 (-)
LP/J MGP_LPJ_G0033206
 protein coding gene Chr7:151481238-151658000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033096
 protein coding gene Chr7:161200789-161369266 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033801
 protein coding gene Chr7:148667860-148831726 (-)
PWK/PhJ MGP_PWKPhJ_G0032020
 protein coding gene Chr7:136883068-137050330 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031864
 protein coding gene Chr7:135448263-135614286 (-)
WSB/EiJ MGP_WSBEiJ_G0032423
 protein coding gene Chr7:149655280-149823959 (-)



Homology
more
  • Human Ortholog
    ANO1, anoctamin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANO1, anoctamin 1
  • Synonyms
    DOG1, INDMS, MYMY7, ORAOV2, TAOS2, TMEM16A
  • Links
    NCBI Gene ID: 55107
    neXtProt AC: NX_Q5XXA6
    UniProt: Q5XXA6

  • Chr Location
    11q13.3; chr11:69965997-70189530 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 6 alleles in 8 genetic backgrounds
    1 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit postnatal death associated with aerophagia, slow postnatal weight gain, cyanosis, and abnormal tracheal morphology. Mice homozygous for a different knock-out allele exhibit proteinuria and intracellular endosomal vesicles in PTE cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1330
  • Tissues
    382
  • cDNA Data
    18
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031075 Ensembl Gene Model | MGI Sequence Detail 163426 C57BL/6J ±  kb
    transcript ENSMUST00000238848 Ensembl | MGI Sequence Detail 4644 Not Applicable  
    polypeptide ENSMUSP00000159034 Ensembl | MGI Sequence Detail 982 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 20
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142269
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 24
      Gene Ontology 22
      Phenotypes 59
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345618 Liu XM, et al., Ano1 regulates embryo transport by modulating intracellular calcium levels in oviduct smooth muscle. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 8;1870(4):167059
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory