About   Help   FAQ
Rnf40 Gene Detail
Summary
  • Symbol
    Rnf40
  • Name
    ring finger protein 40
  • Synonyms
    MGC:19037, mKIAA0661
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142048
    NCBI Gene: 233900
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127187936-127202777 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142048
 protein coding gene Chr7:127187936-127203971 (+)
129S1/SvImJ ENSMUSG00200021899
 protein coding gene Chr7:113700913-113716947 (+)
A/J ENSMUSG00195044902
 protein coding gene Chr7:118215361-118231398 (+)
AKR/J ENSMUSG00220019192
 protein coding gene Chr7:111650022-111666057 (+)
BALB/cJ ENSMUSG00180011099
 protein coding gene Chr7:114890857-114906894 (+)
C3H/HeJ ENSMUSG00175015779
 protein coding gene Chr7:115617767-115633802 (+)
C57BL/6NJ ENSMUSG00215031941
 protein coding gene Chr7:114897645-114913680 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030512
 protein coding gene Chr7:129629602-129646213 (+)
CAST/EiJ ENSTCUG00005048394
 protein coding gene Chr7:118140970-118156990 (+)
CBA/J ENSMUSG00210022658
 protein coding gene Chr7:115378709-115394741 (+)
DBA/2J ENSMUSG00185040703
 protein coding gene Chr7:119691524-119707556 (+)
FVB/NJ ENSMUSG00205033045
 protein coding gene Chr7:115334495-115350528 (+)
JF1/MsJ ENSUMUG00000039220
 protein coding gene Chr7:124755072-124772684 (+)
LP/J ENSMUSG00230051887
 protein coding gene Chr7:125800853-125816885 (+)
NOD/ShiLtJ ENSMUSG00190016557
 protein coding gene Chr7:115537441-115553478 (+)
NZO/HlLtJ ENSMUSG00225010928
 protein coding gene Chr7:124031050-124047085 (+)
PWK/PhJ ENSLUMG00010030524
 protein coding gene Chr7:113892722-113908910 (+)
SPRET/EiJ ENSMSPG00010012593
 protein coding gene Chr7:115155629-115170400 (+)
WSB/EiJ ENSIUOG00005031484
 protein coding gene Chr7:116238244-116254281 (+)



Homology
more
  • Human Ortholog
    RNF40, ring finger protein 40
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF40, ring finger protein 40
  • Synonyms
    BRE1B, RBP95, STARING
  • Links
    NCBI Gene ID: 9810
    UniProt: O75150

  • Chr Location
    16p11.2; chr16:30761612-30776307 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Colon-specific knock-out results in decreased susceptibility to induced colitis and increased bone strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    22
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233900 NCBI Gene Model | MGI Sequence Detail 14842 C57BL/6J ±  kb
    transcript NM_001421781 RefSeq | MGI Sequence Detail 4114 C57BL/6  
    polypeptide Q3U319 UniProt | EBI | MGI Sequence Detail 1001 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:374222 Dou Y, et al., Endothelial RNF20 suppresses endothelial-to-mesenchymal transition and safeguards physiological angiocrine signaling to prevent congenital heart disease. Nat Commun. 2025 Oct 27;16(1):9480
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory