Alkbh6 MGI Mouse Gene Detail - MGI:2142037

Symbol

Alkbh6
Name

alkB homolog 6
Synonyms

Abh6

Feature Type

protein coding gene
IDs

MGI:2142037
NCBI Gene: 233065
Alliance

genome feature page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:30008178-30013728 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 17.38 cM
Mapping Data

1 experiment

SNPs within 2kb

221 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142037	protein coding gene	Chr7:30008142-30013729 (+)
129S1/SvImJ	ENSMUSG00200041001	protein coding gene	Chr7:19789184-19794782 (+)
A/J	ENSMUSG00195039164	protein coding gene	Chr7:22463774-22469397 (+)
AKR/J	ENSMUSG00220053236	protein coding gene	Chr7:22018013-22023630 (-)
BALB/cJ	ENSMUSG00180015408	protein coding gene	Chr7:20523252-20528871 (+)
C3H/HeJ	ENSMUSG00175028846	protein coding gene	Chr7:21596842-21602429 (+)
C57BL/6NJ	ENSMUSG00215054722	protein coding gene	Chr7:19698953-19704541 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029512	protein coding gene	Chr7:29554381-29560171 (+)
CAST/EiJ	ENSTCUG00005040338	protein coding gene	Chr7:21503485-21509102 (+)
CBA/J	ENSMUSG00210025397	protein coding gene	Chr7:20759457-20765046 (+)
DBA/2J	ENSMUSG00185042520	protein coding gene	Chr7:23854431-23860048 (+)
FVB/NJ	ENSMUSG00205015966	protein coding gene	Chr7:20508477-20514064 (+)
JF1/MsJ	ENSUMUG00000046254	protein coding gene	Chr7:28302028-28307650 (+)
LP/J	ENSMUSG00230052343	protein coding gene	Chr7:29024901-29030518 (+)
NOD/ShiLtJ	ENSMUSG00190007921	protein coding gene	Chr7:20189286-20194875 (+)
NZO/HlLtJ	ENSMUSG00225022900	protein coding gene	Chr7:27866528-27872115 (+)
PWK/PhJ	ENSLUMG00010020673	protein coding gene	Chr7:20231065-20236661 (+)
SPRET/EiJ	ENSMSPG00010048983	protein coding gene	Chr7:19593346-19598974 (+)
WSB/EiJ	ENSIUOG00005052258	protein coding gene	Chr7:14477126-14482732 (+)

Human Ortholog

ALKBH6, alkB homolog 6, nucleotide demethylase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALKBH6, alkB homolog 6, nucleotide demethylase
Synonyms

ABH6
Links

HGNC:28243

NCBI Gene ID: 84964

UniProt: Q3KRA9
Chr Location

19q13.12; chr19:36009120-36014297 (-) GRCh38

MGI Vertebrate Homology

Alkbh6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ALKBH6
Gene Tree

Alkbh6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

83

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alkbh6

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All Sequences

50
RefSeq

2
UniProt

3
CCDS

CCDS21085.1

Ensembl

ENSMUSG00000042831 (Evidence)
NCBI Gene

233065

			Length	Strain/Species	Flank
genomic	233065	NCBI Gene Model \| MGI Sequence Detail	5551	C57BL/6J	± kb
transcript	NM_198027	RefSeq \| MGI Sequence Detail	945	C57BL/6
polypeptide	Q8K2U2	UniProt \| EBI \| MGI Sequence Detail	238	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003953 probable RNA/DNA demethylase ALKBH6

(term hierarchy)
EC

1.14.11.-
InterPro Domains

IPR032862 Alpha-ketoglutarate-dependent dioxygenase alkB homologue 6

IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like

IPR037151 Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily

IPR005123 Oxoglutarate/iron-dependent dioxygenase domain

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All nucleic 83

cDNA 83

Microarray probesets 3

Summaries

All 33

Gene Ontology 6

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Alkbh6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65682	Chr7:30006260-30006278 (+)	-1,909 bp
Tssr65683	Chr7:30006281-30006304 (+)	-1,885 bp
Tssr65684	Chr7:30006485-30006526 (+)	-1,672 bp
Tssr65685	Chr7:30006536-30006554 (+)	-1,633 bp
Tssr65686	Chr7:30006572-30006594 (+)	-1,595 bp
Tssr65687	Chr7:30006632-30006655 (+)	-1,534 bp
Tssr65688	Chr7:30006658-30006703 (+)	-1,497 bp
Tssr65689	Chr7:30006741-30006779 (+)	-1,418 bp
Tssr65690	Chr7:30006786-30006803 (+)	-1,383 bp
Tssr65691	Chr7:30007088-30007101 (+)	-1,083 bp
Tssr65692	Chr7:30007691-30007702 (+)	-481 bp
Tssr65693	Chr7:30008166-30008183 (+)	-3 bp
Tssr65694	Chr7:30008185-30008196 (+)	13 bp
Tssr65695	Chr7:30008197-30008243 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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