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Pwwp2b Gene Detail
Summary
  • Symbol
    Pwwp2b
  • Name
    PWWP domain containing 2B
  • Synonyms
    D7Ertd517e, D930023J19Rik, Pwwp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142008
    NCBI Gene: 101631
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:138828398-138847172 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 84.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142008
 protein coding gene Chr7:138828398-138849819 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033149
 protein coding gene Chr7:144259645-144278416 (+)
A/J MGP_AJ_G0033131
 protein coding gene Chr7:140184034-140202817 (+)
AKR/J MGP_AKRJ_G0033063
 protein coding gene Chr7:143962456-143981305 (+)
BALB/cJ MGP_BALBcJ_G0033132
 protein coding gene Chr7:139926245-139945001 (+)
C3H/HeJ MGP_C3HHeJ_G0032846
 protein coding gene Chr7:143780980-143799750 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033643
 protein coding gene Chr7:149581479-149601445 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030616
 protein coding gene Chr7:141324443-141343316 (+)
CAST/EiJ MGP_CASTEiJ_G0032176
 protein coding gene Chr7:136070137-136156145 (+)
CBA/J MGP_CBAJ_G0032819
 protein coding gene Chr7:154633324-154652106 (+)
DBA/2J MGP_DBA2J_G0032971
 protein coding gene Chr7:138143085-138161843 (+)
FVB/NJ MGP_FVBNJ_G0032924
 protein coding gene Chr7:138027175-138045949 (+)
LP/J MGP_LPJ_G0033065
 protein coding gene Chr7:145804152-145822909 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032956
 protein coding gene Chr7:155338497-155357277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033663
 protein coding gene Chr7:142966509-142985283 (+)
PWK/PhJ MGP_PWKPhJ_G0031882
 protein coding gene Chr7:131314456-131393233 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031727
 protein coding gene Chr7:129798571-129817444 (+)
WSB/EiJ MGP_WSBEiJ_G0032287
 protein coding gene Chr7:143880243-143900197 (+)



Homology
more
  • Human Ortholog
    PWWP2B, PWWP domain containing 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PWWP2B, PWWP domain containing 2B
  • Synonyms
    bA432J24.1, pp8607, PWWP2
  • Links
    NCBI Gene ID: 170394
    neXtProt AC: NX_Q6NUJ5
    UniProt: Q6NUJ5

  • Chr Location
    10q26.3; chr10:132397168-132417859 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in adipose tissue exhibit increased adaptive thermogenesis and protection from high-fat diet induced obesity and metabolic dysregulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101631 NCBI Gene Model | MGI Sequence Detail 18775 C57BL/6J ±  kb
    transcript NM_001098636 RefSeq | MGI Sequence Detail 2640 ZRU/MplStud  
    polypeptide E9Q9M8 UniProt | EBI | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 29
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1261860
    References
    more
    • Summaries
      All 33
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:319940 Yan L, et al., PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. Adv Sci (Weinh). 2021 Aug;8(16):e2102060
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory