About   Help   FAQ
Parp11 Gene Detail
Summary
  • Symbol
    Parp11
  • Name
    poly (ADP-ribose) polymerase family, member 11
  • Synonyms
    5330431N24Rik, HIN1L
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141505
    NCBI Gene: 101187
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127423803-127471224 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 62.39 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141505
 protein coding gene Chr6:127423803-127491200 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031314
 protein coding gene Chr6:130962134-131016988 (+)
A/J MGP_AJ_G0031285
 protein coding gene Chr6:125972937-126017912 (+)
AKR/J MGP_AKRJ_G0031213
 protein coding gene Chr6:129371195-129418337 (+)
BALB/cJ MGP_BALBcJ_G0031292
 protein coding gene Chr6:125530644-125578097 (+)
C3H/HeJ MGP_C3HHeJ_G0031016
 protein coding gene Chr6:129505011-129557593 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031749
 protein coding gene Chr6:134384315-134435620 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028897
 protein coding gene Chr6:123144785-123194933 (+)
CAST/EiJ MGP_CASTEiJ_G0030397
 protein coding gene Chr6:129719046-129775887 (+)
CBA/J MGP_CBAJ_G0030977
 protein coding gene Chr6:139544577-139593515 (+)
DBA/2J MGP_DBA2J_G0031133
 protein coding gene Chr6:124861740-124907422 (+)
FVB/NJ MGP_FVBNJ_G0031082
 protein coding gene Chr6:123788270-123833202 (+)
LP/J MGP_LPJ_G0031213
 protein coding gene Chr6:131063807-131111096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031121
 protein coding gene Chr6:143487413-143538178 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031784
 protein coding gene Chr6:129347188-129400329 (+)
PWK/PhJ MGP_PWKPhJ_G0030112
 protein coding gene Chr6:123142483-123189295 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029941
 protein coding gene Chr6:127433945-127487877 (+)
WSB/EiJ MGP_WSBEiJ_G0030482
 protein coding gene Chr6:129711357-129763368 (+)



Homology
more
  • Human Ortholog
    PARP11, poly(ADP-ribose) polymerase family member 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PARP11, poly(ADP-ribose) polymerase family member 11
  • Synonyms
    ARTD11, C12orf6, MIB006
  • Links
    NCBI Gene ID: 57097
    neXtProt AC: NX_Q9NR21
    UniProt: Q9NR21

  • Chr Location
    12p13.32; chr12:3791047-3873448 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired male fertility and teratozoospermia associated with sperm head malformations and nuclear envelope defects during the nuclear reshaping process of spermatid elongation and condensation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    23
  • cDNA Data
    49
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037997 Ensembl Gene Model | MGI Sequence Detail 47422 C57BL/6J ±  kb
    transcript ENSMUST00000039680 Ensembl | MGI Sequence Detail 3746 Not Applicable  
    polypeptide ENSMUSP00000036127 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 49

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:298222 Guo T, et al., ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase beta-TrCP. Nat Microbiol. 2019 Nov;4(11):1872-1884
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory