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Alkbh2 Gene Detail
Summary
  • Symbol
    Alkbh2
  • Name
    alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase
  • Synonyms
    Abh2, mABH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141032
    NCBI Gene: 231642
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114261987-114266279 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141032
 protein coding gene Chr5:114261987-114269293 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029931
 protein coding gene Chr5:116837324-116841592 (-)
A/J MGP_AJ_G0029896
 protein coding gene Chr5:112254177-112258490 (-)
AKR/J MGP_AKRJ_G0029834
 protein coding gene Chr5:115820015-115824304 (-)
BALB/cJ MGP_BALBcJ_G0029907
 protein coding gene Chr5:113622468-113626761 (-)
C3H/HeJ MGP_C3HHeJ_G0029627
 protein coding gene Chr5:116307701-116311988 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030361
 protein coding gene Chr5:121355364-121359650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027589
 protein coding gene Chr5:107079196-107083495 (-)
CAST/EiJ MGP_CASTEiJ_G0029035
 protein coding gene Chr5:115243858-115248152 (-)
CBA/J MGP_CBAJ_G0029594
 protein coding gene Chr5:125952734-125957028 (-)
DBA/2J MGP_DBA2J_G0029744
 protein coding gene Chr5:112313283-112317701 (-)
FVB/NJ MGP_FVBNJ_G0029701
 protein coding gene Chr5:111109372-111114713 (-)
LP/J MGP_LPJ_G0029833
 protein coding gene Chr5:117406299-117410585 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029732
 protein coding gene Chr5:130430399-130434689 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030402
 protein coding gene Chr5:115276355-115282800 (-)
PWK/PhJ MGP_PWKPhJ_G0028749
 protein coding gene Chr5:110941633-110946309 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028587
 protein coding gene Chr5:112816603-112822589 (-)
WSB/EiJ MGP_WSBEiJ_G0029111
 protein coding gene Chr5:115840888-115845207 (-)



Homology
more
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALKBH2, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase
  • Synonyms
    ABH2
  • Links
    NCBI Gene ID: 121642
    neXtProt AC: NX_Q6NS38
    UniProt: Q6NS38

  • Chr Location
    12q24.11; chr12:109088188-109093631 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and overtly normal but show progressive accumulation of 1-methyladenine (1meA) in their genomic DNA due to impaired DNA repair. Mutant MEFs fail to remove methyl methane sulfate (MMS)-induced 1meA from genomic DNA and showincreased cytotoxicity after MMS exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044339 Ensembl Gene Model | MGI Sequence Detail 4293 C57BL/6J ±  kb
transcript ENSMUST00000053657 Ensembl | MGI Sequence Detail 1073 Not Applicable  
polypeptide ENSMUSP00000056043 Ensembl | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:299035 Jordan JJ, et al., ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death Dis. 2017 Jul 20;8(7):e2947
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory