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Oas1d Gene Detail
Summary
  • Symbol
    Oas1d
  • Name
    2'-5' oligoadenylate synthetase 1D
Location &
Maps
more
  • Sequence Map
    Chr5:121052881-121059711 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.87 cM, cytoband F
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140770
 protein coding gene Chr5:121052599-121059715 (+)
129S1/SvImJ ENSMUSG00200024263
 protein coding gene Chr5:114791836-114798948 (+)
A/J ENSMUSG00195010749
 protein coding gene Chr5:114313038-114320150 (+)
AKR/J ENSMUSG00220045169
 protein coding gene Chr5:113813938-113821058 (+)
BALB/cJ ENSMUSG00180032616
 protein coding gene Chr5:114427628-114434740 (+)
C3H/HeJ ENSMUSG00175020798
 protein coding gene Chr5:116425659-116432777 (+)
C57BL/6NJ ENSMUSG00215043262
 protein coding gene Chr5:114459537-114466654 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005038151
 protein coding gene Chr5:113696538-113703725 (+)
CBA/J ENSMUSG00210007345
 protein coding gene Chr5:115176534-115183648 (+)
DBA/2J ENSMUSG00185052911
 protein coding gene Chr5:118235878-118242994 (+)
FVB/NJ ENSMUSG00205043521
 protein coding gene Chr5:114089667-114096779 (+)
JF1/MsJ ENSUMUG00000050348
 protein coding gene Chr5:121078783-121085932 (+)
LP/J ENSMUSG00230039667
 protein coding gene Chr5:122314029-122321141 (+)
NOD/ShiLtJ ENSMUSG00190025056
 protein coding gene Chr5:114123738-114130850 (+)
NZO/HlLtJ ENSMUSG00225014266
 protein coding gene Chr5:129991165-129998285 (+)
PWK/PhJ ENSLUMG00010029866
 protein coding gene Chr5:112981322-112988455 (+)
SPRET/EiJ ENSMSPG00010034496
 protein coding gene Chr5:116305510-116313124 (+)
WSB/EiJ ENSIUOG00005016844
 protein coding gene Chr5:116807978-116815090 (+)



Homology
more
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OAS1, 2'-5'-oligoadenylate synthetase 1
  • Synonyms
    E18/E16, IFI-4, IMD100, OIAS, OIASI
  • Links
    NCBI Gene ID: 4938
    UniProt: P00973

  • Chr Location
    12q24.13; chr12:112905856-112933219 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human OAS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null females exhibit reduced fertility due to defects in ovarian follicle development and decreased efficiency of ovulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    614
  • Tissues
    12
  • cDNA Data
    82
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100535 NCBI Gene Model | MGI Sequence Detail 6831 C57BL/6J ±  kb
    transcript NM_133893 RefSeq | MGI Sequence Detail 1750 ZRU/MplStud  
    polypeptide Q8VI95 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR018952 2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal
      IPR043519 Nucleotidyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 82
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141327
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:192649 Kristiansen H, et al., The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. J Interferon Cytokine Res. 2011 Jan;31(1):41-7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory