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Snph Gene Detail
Summary
  • Symbol
    Snph
  • Name
    syntaphilin
  • Synonyms
    mKIAA0374
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139270
    NCBI Gene: 241727
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151432469-151474513 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139270
 protein coding gene Chr2:151432469-151474527 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026642
 protein coding gene Chr2:156076112-156119326 (-)
A/J MGP_AJ_G0026608
 protein coding gene Chr2:149868914-149910872 (-)
AKR/J MGP_AKRJ_G0026578
 protein coding gene Chr2:154240570-154282462 (-)
BALB/cJ MGP_BALBcJ_G0026617
 protein coding gene Chr2:150181386-150223285 (-)
C3H/HeJ MGP_C3HHeJ_G0026360
 protein coding gene Chr2:154628892-154670830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027066
 protein coding gene Chr2:160631136-160673676 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024437
 protein coding gene Chr2:143482547-143524068 (-)
CAST/EiJ MGP_CASTEiJ_G0025821
 protein coding gene Chr2:154846895-154889969 (-)
CBA/J MGP_CBAJ_G0026338
 protein coding gene Chr2:166509135-166553790 (-)
DBA/2J MGP_DBA2J_G0026474
 protein coding gene Chr2:149084366-149126264 (-)
FVB/NJ MGP_FVBNJ_G0026439
 protein coding gene Chr2:147530967-147572955 (-)
LP/J MGP_LPJ_G0026578
 protein coding gene Chr2:156247831-156291178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026461
 protein coding gene Chr2:170670585-170719184 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027121
 protein coding gene Chr2:154114744-154157581 (-)
PWK/PhJ MGP_PWKPhJ_G0025555
 protein coding gene Chr2:148611410-148654110 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025358
 protein coding gene Chr2:152951860-152993870 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SNPH, syntaphilin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNPH, syntaphilin
  • Links
    NCBI Gene ID: 9751
    neXtProt AC: NX_O15079
    UniProt: O15079

  • Chr Location
    20p13; chr20:1266280-1309328 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with disruptions in this gene are viable, fertile, and morphologically normal. However, they do display subtile deficiencies in coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    27
  • cDNA Data
    41
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027457 Ensembl Gene Model | MGI Sequence Detail 42045 C57BL/6J ±  kb
    transcript ENSMUST00000028951 Ensembl | MGI Sequence Detail 4730 Not Applicable  
    polypeptide ENSMUSP00000028951 Ensembl | MGI Sequence Detail 528 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139400, MGI:2139413
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:286278 Han Q, et al., Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury. Cell Metab. 2020 Mar 3;31(3):623-641.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory