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Osbpl6 Gene Detail
Summary
  • Symbol
    Osbpl6
  • Name
    oxysterol binding protein-like 6
  • Synonyms
    1110062M20Rik, ORP-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139014
    NCBI Gene: 99031
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:76236852-76430991 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 44.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5857 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139014
 protein coding gene Chr2:76236848-76430991 (+)
129S1/SvImJ ENSMUSG00200003553
 protein coding gene Chr2:73287887-73475530 (+)
A/J ENSMUSG00195016885
 protein coding gene Chr2:73436499-73624218 (+)
AKR/J ENSMUSG00220001961
 protein coding gene Chr2:73395306-73589636 (+)
BALB/cJ ENSMUSG00180006642
 protein coding gene Chr2:73390152-73577840 (+)
C3H/HeJ ENSMUSG00175010623
 protein coding gene Chr2:73513368-73701019 (+)
C57BL/6NJ ENSMUSG00215011748
 protein coding gene Chr2:73349695-73543950 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023687
 protein coding gene Chr2:71221853-71408460 (+)
CAST/EiJ ENSTCUG00005028526
 protein coding gene Chr2:72830068-73015902 (+)
CBA/J ENSMUSG00210001964
 protein coding gene Chr2:73552688-73740389 (+)
DBA/2J ENSMUSG00185010437
 protein coding gene Chr2:73388496-73576192 (+)
FVB/NJ ENSMUSG00205012676
 protein coding gene Chr2:72840602-73034930 (+)
JF1/MsJ ENSUMUG00000028081
 protein coding gene Chr2:73080578-73269156 (+)
LP/J ENSMUSG00230024954
 protein coding gene Chr2:75194655-75382277 (+)
NOD/ShiLtJ ENSMUSG00190010239
 protein coding gene Chr2:73465156-73652606 (+)
NZO/HlLtJ ENSMUSG00225002182
 protein coding gene Chr2:82957723-83145031 (+)
PWK/PhJ ENSLUMG00010030603
 protein coding gene Chr2:73303511-73492919 (+)
SPRET/EiJ ENSMSPG00010018967
 protein coding gene Chr2:74780712-74877480 (+)
WSB/EiJ ENSIUOG00005010716
 protein coding gene Chr2:73516959-73716520 (+)



Homology
more
  • Human Ortholog
    OSBPL6, oxysterol binding protein like 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OSBPL6, oxysterol binding protein like 6
  • Synonyms
    ORP6
  • Links
    NCBI Gene ID: 114880
    UniProt: Q9BZF3

  • Chr Location
    2q31.2; chr2:178193711-178402893 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    881
  • Tissues
    55
  • cDNA Data
    42
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042359 Ensembl Gene Model | MGI Sequence Detail 194140 C57BL/6J ±  kb
    transcript ENSMUST00000077972 Ensembl | MGI Sequence Detail 8037 Not Applicable  
    polypeptide ENSMUSP00000077123 Ensembl | MGI Sequence Detail 967 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000012051 oxysterol-binding protein-related protein 6
      (term hierarchy)
    • InterPro Domains
      IPR000648 Oxysterol-binding protein
      IPR018494 Oxysterol-binding protein, conserved site
      IPR037239 Oxysterol-binding protein superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR041680 Pleckstrin homology domain 8
    • GlyGen
      Q8BXR9 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 42
      Primer pair 3
      Other 2
      Antibodies 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1916103
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:379978 Kasongo AA, et al., Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Abeta production. J Lipid Res. 2025 Sep;66(9):100868
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory