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Dgkd Gene Detail
Summary
  • Symbol
    Dgkd
  • Name
    diacylglycerol kinase, delta
  • Synonyms
    dgkd-2, DGKdelta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138334
    NCBI Gene: 227333
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87781009-87872902 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 44.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    327 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138334
 protein coding gene Chr1:87780942-87872902 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016271
 protein coding gene Chr1:89240471-89338720 (+)
A/J MGP_AJ_G0016252
 protein coding gene Chr1:85889798-85981246 (+)
AKR/J MGP_AKRJ_G0016213
 protein coding gene Chr1:88430858-88529143 (+)
BALB/cJ MGP_BALBcJ_G0016209
 protein coding gene Chr1:86007124-86109816 (+)
C3H/HeJ MGP_C3HHeJ_G0016037
 protein coding gene Chr1:88701360-88799388 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016666
 protein coding gene Chr1:92544168-92646125 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014387
 protein coding gene Chr1:80335364-80425334 (+)
CAST/EiJ MGP_CASTEiJ_G0015622
 protein coding gene Chr1:87898458-87996615 (+)
CBA/J MGP_CBAJ_G0016013
 protein coding gene Chr1:95515627-95617709 (+)
DBA/2J MGP_DBA2J_G0016116
 protein coding gene Chr1:85180755-85271515 (+)
FVB/NJ MGP_FVBNJ_G0016115
 protein coding gene Chr1:84243234-84336164 (+)
LP/J MGP_LPJ_G0016187
 protein coding gene Chr1:90276629-90369932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016141
 protein coding gene Chr1:98769790-98869594 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016708
 protein coding gene Chr1:88542497-88638883 (+)
PWK/PhJ MGP_PWKPhJ_G0015409
 protein coding gene Chr1:84491801-84584484 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015189
 protein coding gene Chr1:87434438-87526022 (+)
WSB/EiJ MGP_WSBEiJ_G0015686
 protein coding gene Chr1:88204490-88302745 (+)



Homology
more
  • Human Ortholog
    DGKD, diacylglycerol kinase delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKD, diacylglycerol kinase delta
  • Synonyms
    dgkd-2, DGKdelta, DGK-delta
  • Links
    NCBI Gene ID: 8527
    neXtProt AC: NX_Q16760
    UniProt: Q16760

  • Chr Location
    2q37.1; chr2:233354494-233472104 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dgkd mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are born with open eyelids and reduced body size, develop respiratory distress and die within 24 hrs of birth. Half of mice homozygous for a hypomorphic gene trap allele exhibit abnormal epileptic discharges and seizureswhile 9% of aging homozygotes develop tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    31
  • cDNA Data
    201
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070738 Ensembl Gene Model | MGI Sequence Detail 91894 C57BL/6J ±  kb
    transcript ENSMUST00000027517 Ensembl | MGI Sequence Detail 5695 Not Applicable  
    polypeptide ENSMUSP00000027517 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000006444 diacylglycerol kinase delta
      (term hierarchy)
    • EC
      2.7.1.107
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR047478 Diacylglycerol kinase delta, first protein kinase C conserved region 1
      IPR037606 Diacylglycerol kinase delta, SAM domain
      IPR047477 Diacylglycerol kinase delta, second protein kinase C conserved region 1
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 204
      cDNA 201
      Primer pair 3

      Microarray probesets 7
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:284261 Lu Q, et al., Diacylglycerol kinase delta destabilizes serotonin transporter protein through the ubiquitin-proteasome system. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Mar;1865(3):158608
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory