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Slc24a3 Gene Detail
Summary
  • Symbol
    Slc24a3
  • Name
    solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
  • Synonyms
    NCKX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137513
    NCBI Gene: 94249
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:145009695-145484086 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 71.08 cM, cytoband H1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12023 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137513
 protein coding gene Chr2:145009674-145484086 (+)
129S1/SvImJ ENSMUSG00200006835
 protein coding gene Chr2:142091804-142582469 (+)
A/J ENSMUSG00195020291
 protein coding gene Chr2:142247694-142722668 (+)
AKR/J ENSMUSG00220037194
 protein coding gene Chr2:141801363-142292060 (+)
BALB/cJ ENSMUSG00180038124
 protein coding gene Chr2:141909404-142384507 (+)
C3H/HeJ ENSMUSG00175037844
 protein coding gene Chr2:142456463-142931551 (+)
C57BL/6NJ ENSMUSG00215017636
 protein coding gene Chr2:141965336-142446227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024391
 protein coding gene Chr2:137402786-137868259 (+)
CAST/EiJ ENSTCUG00005010789
 protein coding gene Chr2:141105595-141578395 (+)
CBA/J ENSMUSG00210037612
 protein coding gene Chr2:142375724-142850780 (+)
DBA/2J ENSMUSG00185039749
 protein coding gene Chr2:141970403-142461014 (+)
FVB/NJ ENSMUSG00205026156
 protein coding gene Chr2:141171632-141656702 (+)
JF1/MsJ ENSUMUG00000030474
 protein coding gene Chr2:141759579-142250447 (+)
LP/J ENSMUSG00230029011
 protein coding gene Chr2:143674471-144165117 (+)
NOD/ShiLtJ ENSMUSG00190036638
 protein coding gene Chr2:142043950-142519019 (+)
NZO/HlLtJ ENSMUSG00225001158
 protein coding gene Chr2:151662672-152153376 (+)
PWK/PhJ ENSLUMG00010039956
 protein coding gene Chr2:141789328-142278765 (+)
SPRET/EiJ ENSMSPG00010023623
 protein coding gene Chr2:144288511-144781926 (+)
WSB/EiJ ENSIUOG00005022866
 protein coding gene Chr2:141812124-142286899 (+)



Homology
more
  • Human Ortholog
    SLC24A3, solute carrier family 24 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC24A3, solute carrier family 24 member 3
  • Synonyms
    NCKX3
  • Links
    NCBI Gene ID: 57419
    UniProt: Q9HC58

  • Chr Location
    20p11.23; chr20:19212510-19722926 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mice show reduced bone mineral content, density and bone strength, thinner compact bone, increased parathyroid hormone level, shorter duodenum villus length, increased severity of induced colitis, increased depression-related behavior, and motor learning and sociability deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    41
  • cDNA Data
    25
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94249 NCBI Gene Model | MGI Sequence Detail 474392 C57BL/6J ±  kb
    transcript NM_001356497 RefSeq | MGI Sequence Detail 4027 C57BL/6  
    polypeptide Q99PD7 UniProt | EBI | MGI Sequence Detail 645 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000015000 sodium/potassium/calcium exchanger 3
      (term hierarchy)
    • InterPro Domains
      IPR044880 NCX, central ion-binding domain superfamily
      IPR004837 Sodium/calcium exchanger membrane region
      IPR004481 Sodium/potassium/calcium exchanger
    • GlyGen
      Q99PD7 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory