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Lrfn1 Gene Detail
Summary
  • Symbol
    Lrfn1
  • Name
    leucine rich repeat and fibronectin type III domain containing 1
  • Synonyms
    MGC:7599, SALM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136810
    NCBI Gene: 80749
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28151405-28167667 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.77 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136810
 protein coding gene Chr7:28151194-28167667 (+)
129S1/SvImJ ENSMUSG00200042465
 protein coding gene Chr7:17937437-17953710 (+)
A/J ENSMUSG00195048701
 protein coding gene Chr7:20610445-20626774 (+)
AKR/J ENSMUSG00220047462
 protein coding gene Chr7:23859024-23875292 (-)
BALB/cJ ENSMUSG00180046141
 protein coding gene Chr7:18669988-18686314 (+)
C3H/HeJ ENSMUSG00175047489
 protein coding gene Chr7:19705609-19721878 (+)
C57BL/6NJ ENSMUSG00215053837
 protein coding gene Chr7:17841220-17857491 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029449
 protein coding gene Chr7:27650049-27665999 (+)
CAST/EiJ ENSTCUG00005050300
 protein coding gene Chr7:19636268-19652380 (+)
CBA/J ENSMUSG00210051579
 protein coding gene Chr7:18890201-18906469 (+)
DBA/2J ENSMUSG00185047723
 protein coding gene Chr7:22002886-22019153 (+)
FVB/NJ ENSMUSG00205049136
 protein coding gene Chr7:18676007-18692290 (+)
JF1/MsJ ENSUMUG00000019284
 protein coding gene Chr7:26404109-26420178 (+)
LP/J ENSMUSG00230051773
 protein coding gene Chr7:27173419-27189684 (+)
NOD/ShiLtJ ENSMUSG00190049469
 protein coding gene Chr7:18337175-18353449 (+)
NZO/HlLtJ ENSMUSG00225024416
 protein coding gene Chr7:26016542-26032819 (+)
PWK/PhJ ENSLUMG00010048679
 protein coding gene Chr7:18368082-18384069 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005053342
 protein coding gene Chr7:12597805-12614073 (+)



Homology
more
  • Human Ortholog
    LRFN1, leucine rich repeat and fibronectin type III domain containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRFN1, leucine rich repeat and fibronectin type III domain containing 1
  • Synonyms
    SALM2
  • Links
    NCBI Gene ID: 57622
    UniProt: Q9P244

  • Chr Location
    19q13.2; chr19:39306566-39320966 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    663
  • Tissues
    60
  • cDNA Data
    14
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030600 Ensembl Gene Model | MGI Sequence Detail 16263 C57BL/6J ±  kb
transcript ENSMUST00000108288 Ensembl | MGI Sequence Detail 3060 Not Applicable  
polypeptide ENSMUSP00000103923 Ensembl | MGI Sequence Detail 766 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009912 leucine-rich repeat and fibronectin type III domain-containing protein 1
    (term hierarchy)
  • PDB
    5XWU
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR003599 Immunoglobulin domain subtype
    IPR013098 Immunoglobulin I-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003598 Immunoglobulin subtype 2
    IPR001611 Leucine-rich repeat
    IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    Q2WF71 6 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 14
    Primer pair 1
    Other 2

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory