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Sbk1 Gene Detail
Summary
  • Symbol
    Sbk1
  • Name
    SH3-binding kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135937
    NCBI Gene: 104175
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:125848034-125894188 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.01 cM, cytoband F1-F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135937
 protein coding gene Chr7:125847524-125894188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032974
 protein coding gene Chr7:130521910-130546274 (+)
A/J MGP_AJ_G0032957
 protein coding gene Chr7:127087538-127109899 (+)
AKR/J MGP_AKRJ_G0032889
 protein coding gene Chr7:130297043-130320937 (+)
BALB/cJ MGP_BALBcJ_G0032962
 protein coding gene Chr7:126744278-126767376 (+)
C3H/HeJ MGP_C3HHeJ_G0032672
 protein coding gene Chr7:130221905-130244282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033468
 protein coding gene Chr7:135613691-135636249 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030440
 protein coding gene Chr7:128288102-128310002 (+)
CAST/EiJ MGP_CASTEiJ_G0032000
 protein coding gene Chr7:122019022-122041139 (+)
CBA/J MGP_CBAJ_G0032645
 protein coding gene Chr7:140178130-140200538 (+)
DBA/2J MGP_DBA2J_G0032797
 protein coding gene Chr7:125064405-125087220 (+)
FVB/NJ MGP_FVBNJ_G0032750
 protein coding gene Chr7:124906141-124929503 (+)
LP/J MGP_LPJ_G0032891
 protein coding gene Chr7:131982712-132004937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032782
 protein coding gene Chr7:141385585-141409576 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033488
 protein coding gene Chr7:129309795-129332956 (+)
PWK/PhJ MGP_PWKPhJ_G0031708
 protein coding gene Chr7:118050076-118072613 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031554
 protein coding gene Chr7:116130678-116152781 (+)
WSB/EiJ MGP_WSBEiJ_G0032113
 protein coding gene Chr7:130276017-130298709 (+)



Homology
more
  • Human Ortholog
    SBK1, SH3 domain binding kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SBK1, SH3 domain binding kinase 1
  • Synonyms
    SBK
  • Links
    NCBI Gene ID: 388228
    neXtProt AC: NX_Q52WX2
    UniProt: Q52WX2

  • Chr Location
    16p12.1; chr16:28258681-28323849 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    106
  • cDNA Data
    343
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042978 Ensembl Gene Model | MGI Sequence Detail 46155 C57BL/6J ±  kb
    transcript ENSMUST00000239081 Ensembl | MGI Sequence Detail 1512 Not Applicable  
    polypeptide ENSMUSP00000159131 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 345
      Genomic 1
      cDNA 343
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:69266 Nara K, et al., Cloning and characterization of a novel serine/threonine protein kinase gene expressed predominantly in developing brain. Eur J Biochem. 2001 May;268(9):2642-51
    • Latest
      J:344939 Ahuja P, et al., Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77-FGF21 pathway. Hepatology. 2023 Jan 1;77(1):213-229
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory