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Dync1li1 Gene Detail
Summary
  • Symbol
    Dync1li1
  • Name
    dynein cytoplasmic 1 light intermediate chain 1
  • Synonyms
    1110053F02Rik, Dlic1, Dnclic1, LIC-1, MGC:32416
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135610
    NCBI Gene: 235661
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114517899-114552856 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135610
 protein coding gene Chr9:114517858-114553370 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035392
 protein coding gene Chr9:117143842-117183149 (+)
A/J MGP_AJ_G0035372
 protein coding gene Chr9:112852144-112888822 (+)
AKR/J MGP_AKRJ_G0035305
 protein coding gene Chr9:115723846-115759151 (+)
BALB/cJ MGP_BALBcJ_G0035368
 protein coding gene Chr9:112658979-112696186 (+)
C3H/HeJ MGP_C3HHeJ_G0035076
 protein coding gene Chr9:116224763-116261467 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035891
 protein coding gene Chr9:120346959-120387406 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032774
 protein coding gene Chr9:110150717-110188328 (+)
CAST/EiJ MGP_CASTEiJ_G0034381
 protein coding gene Chr9:116092145-116132297 (+)
CBA/J MGP_CBAJ_G0035043
 protein coding gene Chr9:124855223-124901692 (+)
DBA/2J MGP_DBA2J_G0035202
 protein coding gene Chr9:112326659-112362401 (+)
FVB/NJ MGP_FVBNJ_G0035149
 protein coding gene Chr9:111152216-111187977 (+)
LP/J MGP_LPJ_G0035281
 protein coding gene Chr9:117481129-117518462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035190
 protein coding gene Chr9:126088913-126129202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035910
 protein coding gene Chr9:116100115-116136739 (+)
PWK/PhJ MGP_PWKPhJ_G0034087
 protein coding gene Chr9:112632094-112670176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033921
 protein coding gene Chr9:116141291-116179691 (+)
WSB/EiJ MGP_WSBEiJ_G0034501
 protein coding gene Chr9:115975631-116017840 (+)



Homology
more
  • Human Ortholog
    DYNC1LI1, dynein cytoplasmic 1 light intermediate chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC1LI1, dynein cytoplasmic 1 light intermediate chain 1
  • Synonyms
    DLC-A, DLIC-1, DNCLI1, LIC1
  • Links
    NCBI Gene ID: 51143
    neXtProt AC: NX_Q9Y6G9
    UniProt: Q9Y6G9

  • Chr Location
    3p22.3; chr3:32525974-32570858 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit increased anxiety-related response, increased dendrite length, increased neuron migration, and decreased lysosome trafficking.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    84
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 235661 NCBI Gene Model | MGI Sequence Detail 34958 C57BL/6J ±  kb
    transcript NM_146229 RefSeq | MGI Sequence Detail 2046 C57BL/6  
    polypeptide Q8R1Q8 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006773 cytoplasmic dynein 1 light intermediate chain 1
      (term hierarchy)
    • InterPro Domains
      IPR008467 Dynein 1 light intermediate chain
      IPR022780 Dynein family light intermediate chain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 84

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916070
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
    • Latest
      J:342799 Zhang Y, et al., Dync1li1 is required for the survival of mammalian cochlear hair cells by regulating the transportation of autophagosomes. PLoS Genet. 2022 Jun;18(6):e1010232
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory