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Igsf9 Gene Detail
Summary
  • Symbol
    Igsf9
  • Name
    immunoglobulin superfamily, member 9
  • Synonyms
    Dasm1, mKIAA1355, NRT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135283
    NCBI Gene: 93842
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172309355-172326445 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.86 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    423 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135283
 protein coding gene Chr1:172307616-172326445 (+)
129S1/SvImJ ENSMUSG00200043940
 protein coding gene Chr1:170249519-170264079 (+)
A/J ENSMUSG00195045356
 protein coding gene Chr1:169551432-169566029 (+)
AKR/J ENSMUSG00220029391
 protein coding gene Chr1:169282196-169296754 (+)
BALB/cJ ENSMUSG00180040715
 protein coding gene Chr1:169878180-169892743 (+)
C3H/HeJ ENSMUSG00175043562
 protein coding gene Chr1:169889142-169903701 (+)
C57BL/6NJ ENSMUSG00215043476
 protein coding gene Chr1:169269629-169284226 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014897
 protein coding gene Chr1:162752787-162769811 (+)
CAST/EiJ ENSTCUG00005043635
 protein coding gene Chr1:167841046-167855647 (+)
CBA/J ENSMUSG00210036668
 protein coding gene Chr1:169755619-169770210 (+)
DBA/2J ENSMUSG00185027781
 protein coding gene Chr1:174057728-174072320 (+)
FVB/NJ ENSMUSG00205036330
 protein coding gene Chr1:168737751-168752337 (+)
JF1/MsJ ENSUMUG00000006257
 protein coding gene Chr1:172985912-173000501 (+)
LP/J ENSMUSG00230026473
 protein coding gene Chr1:173654349-173668909 (+)
NOD/ShiLtJ ENSMUSG00190038556
 protein coding gene Chr1:169564606-169579166 (+)
NZO/HlLtJ ENSMUSG00225004182
 protein coding gene Chr1:177235226-177249785 (+)
PWK/PhJ ENSLUMG00010030258
 protein coding gene Chr1:168518434-168533061 (+)
SPRET/EiJ ENSMSPG00010048170
 protein coding gene Chr1:171871568-171886175 (+)
WSB/EiJ ENSIUOG00005033433
 protein coding gene Chr1:168901712-168916290 (+)



Homology
more
  • Human Ortholog
    IGSF9, immunoglobulin superfamily member 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGSF9, immunoglobulin superfamily member 9
  • Synonyms
    FP18798, IGSF9A, Nrt1
  • Links
    NCBI Gene ID: 57549
    UniProt: Q9P2J2

  • Chr Location
    1q23.2; chr1:159927039-159949468 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile but show abnormal miniature inhibitory postsynaptic currents and increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    69
  • cDNA Data
    105
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037995 Ensembl Gene Model | MGI Sequence Detail 17091 C57BL/6J ±  kb
    transcript ENSMUST00000052629 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000058275 Ensembl | MGI Sequence Detail 1179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      Genomic 1
      cDNA 106
      Primer pair 4
      Other 3
      Antibodies 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2135331
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:68343 Doudney K, et al., Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. Genomics. 2001 Mar 1;72(2):180-92
    • Latest
      J:383399 Zhang J, et al., Tumor-associated macrophages educated by IGSF9 exhibit a senescence-associated secretory phenotype to promote tumor immune escape. J Immunother Cancer. 2026 Jan 14;14(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory