About   Help   FAQ
Klf7 Gene Detail
Summary
  • Symbol
    Klf7
  • Name
    Kruppel-like transcription factor 7 (ubiquitous)
  • Synonyms
    9830124P08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935151
    NCBI Gene: 93691
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:64068606-64161441 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.31 cM, cytoband C1-C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935151
 protein coding gene Chr1:64068606-64161504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016094
 protein coding gene Chr1:64203619-64299549 (-)
A/J MGP_AJ_G0016077
 protein coding gene Chr1:61933955-62027131 (-)
AKR/J MGP_AKRJ_G0016034
 protein coding gene Chr1:63660082-63748259 (-)
BALB/cJ MGP_BALBcJ_G0016032
 protein coding gene Chr1:62022500-62115832 (-)
C3H/HeJ MGP_C3HHeJ_G0015864
 protein coding gene Chr1:63948165-64041560 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016485
 protein coding gene Chr1:66684264-66778548 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014206
 protein coding gene Chr1:58009234-58104531 (-)
CAST/EiJ MGP_CASTEiJ_G0015447
 protein coding gene Chr1:63211341-63306128 (-)
CBA/J MGP_CBAJ_G0015836
 protein coding gene Chr1:68846507-68949006 (-)
DBA/2J MGP_DBA2J_G0015937
 protein coding gene Chr1:61354748-61447849 (-)
FVB/NJ MGP_FVBNJ_G0015940
 protein coding gene Chr1:60631838-60726784 (-)
LP/J MGP_LPJ_G0016009
 protein coding gene Chr1:65097778-65198582 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015960
 protein coding gene Chr1:71734711-71834534 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016532
 protein coding gene Chr1:63653031-63752859 (-)
PWK/PhJ MGP_PWKPhJ_G0015234
 protein coding gene Chr1:60724118-60819467 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015013
 protein coding gene Chr1:63157189-63250065 (-)
WSB/EiJ MGP_WSBEiJ_G0015509
 protein coding gene Chr1:63359185-63455214 (-)



Homology
more
  • Human Ortholog
    KLF7, KLF transcription factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF7, KLF transcription factor 7
  • Synonyms
    UKLF
  • Links
    NCBI Gene ID: 8609
    neXtProt AC: NX_O75840
    UniProt: O75840

  • Chr Location
    2q33.3; chr2:207074137-207173856 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    978
  • Tissues
    160
  • cDNA Data
    15
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025959 Ensembl Gene Model | MGI Sequence Detail 92836 C57BL/6J ±  kb
    transcript ENSMUST00000114086 Ensembl | MGI Sequence Detail 7662 Not Applicable  
    polypeptide ENSMUSP00000109720 Ensembl | MGI Sequence Detail 301 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 15
      Primer pair 3
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2445036
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 22
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:341951 Yang X, et al., KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCzeta/NF-kappaB pathway. FASEB J. 2023 Jul;37(7):e23033
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory