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Gpr84 Gene Detail
Summary
  • Symbol
    Gpr84
  • Name
    G protein-coupled receptor 84
  • Synonyms
    EX33
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934129
    NCBI Gene: 80910
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103216662-103219039 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.88 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934129
 protein coding gene Chr15:103216660-103219050 (-)
129S1/SvImJ ENSMUSG00200048194
 protein coding gene Chr15:100441706-100444083 (-)
A/J ENSMUSG00195040875
 protein coding gene Chr15:100330783-100333153 (-)
AKR/J ENSMUSG00220046922
 protein coding gene Chr15:100301681-100304052 (-)
BALB/cJ ENSMUSG00180043751
 protein coding gene Chr15:100214404-100216783 (-)
C3H/HeJ ENSMUSG00175036909
 protein coding gene Chr15:100537920-100540288 (-)
C57BL/6NJ ENSMUSG00215050723
 protein coding gene Chr15:100257793-100260170 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020376
 protein coding gene Chr15:97154639-97156821 (-)
CAST/EiJ ENSTCUG00005043223
 protein coding gene Chr15:99732866-99735245 (-)
CBA/J ENSMUSG00210025905
 protein coding gene Chr15:100283752-100286120 (-)
DBA/2J ENSMUSG00185035395
 protein coding gene Chr15:100300734-100303100 (-)
FVB/NJ ENSMUSG00205028110
 protein coding gene Chr15:100005523-100007889 (-)
JF1/MsJ ENSUMUG00000051118
 protein coding gene Chr15:99760966-99763346 (-)
LP/J ENSMUSG00230006006
 protein coding gene Chr15:103662692-103665069 (-)
NOD/ShiLtJ ENSMUSG00190025172
 protein coding gene Chr15:100245524-100247890 (-)
NZO/HlLtJ ENSMUSG00225026861
 protein coding gene Chr15:103846885-103849253 (-)
PWK/PhJ ENSLUMG00010047787
 protein coding gene Chr15:99972422-99974796 (-)
SPRET/EiJ ENSMSPG00010045474
 protein coding gene Chr15:101755703-101758080 (-)
WSB/EiJ ENSIUOG00005028854
 protein coding gene Chr15:100384701-100387069 (-)



Homology
more
  • Human Ortholog
    GPR84, G protein-coupled receptor 84
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR84, G protein-coupled receptor 84
  • Synonyms
    EX33, GPCR4
  • Links
    NCBI Gene ID: 53831
    UniProt: Q9NQS5

  • Chr Location
    12q13.13; chr12:54350698-54364487 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    11
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063234 Ensembl Gene Model | MGI Sequence Detail 2378 C57BL/6J ±  kb
    transcript ENSMUST00000079824 Ensembl | MGI Sequence Detail 1725 Not Applicable  
    polypeptide ENSMUSP00000078753 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 1
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 31
    • Earliest
      J:68335 Wittenberger T, et al., An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol. 2001 Mar 30;307(3):799-813
    • Latest
      J:390532 Philbrook P, et al., Medium-Chain Fatty Acid Receptor GPR84 Modulates Cytotoxic CD8 T-cell Antitumor Immunity through Metabolic Reprogramming. Cancer Immunol Res. 2026 Apr 2;14(4):640-657
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory