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Tas1r2 Gene Detail
Summary
  • Symbol
    Tas1r2
  • Name
    taste receptor, type 1, member 2
  • Synonyms
    Gpr71, T1r2, TR2
Location &
Maps
more
  • Sequence Map
    Chr4:139380849-139397591 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.82 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    662 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933546
 protein coding gene Chr4:139380849-139397591 (+)
129S1/SvImJ ENSMUSG00200041988
 protein coding gene Chr4:132796268-132812995 (+)
A/J ENSMUSG00195035055
 protein coding gene Chr4:134139853-134156597 (+)
AKR/J ENSMUSG00220046007
 protein coding gene Chr4:133138551-133154895 (+)
BALB/cJ ENSMUSG00180043569
 protein coding gene Chr4:131778514-131794856 (+)
C3H/HeJ ENSMUSG00175032666
 protein coding gene Chr4:132806594-132822941 (+)
C57BL/6NJ ENSMUSG00215047397
 protein coding gene Chr4:134325354-134342100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026717
 protein coding gene Chr4:129327022-129344850 (+)
CAST/EiJ ENSTCUG00005012599
 protein coding gene Chr4:133764843-133781682 (+)
CBA/J ENSMUSG00210028504
 protein coding gene Chr4:132430616-132446956 (+)
DBA/2J ENSMUSG00185050060
 protein coding gene Chr4:133944334-133960673 (+)
FVB/NJ ENSMUSG00205039469
 protein coding gene Chr4:132196334-132212647 (+)
JF1/MsJ ENSUMUG00000031807
 protein coding gene Chr4:134637904-134654609 (+)
LP/J ENSMUSG00230036564
 protein coding gene Chr4:137734856-137751593 (+)
NOD/ShiLtJ ENSMUSG00190023643
 protein coding gene Chr4:132198663-132215406 (+)
NZO/HlLtJ ENSMUSG00225007797
 protein coding gene Chr4:143689551-143706295 (+)
PWK/PhJ ENSLUMG00010042669
 protein coding gene Chr4:131624433-131640767 (+)
SPRET/EiJ ENSMSPG00010032192
 protein coding gene Chr4:133680558-133696997 (+)
WSB/EiJ ENSIUOG00005042403
 protein coding gene Chr4:132084137-132100489 (+)



Homology
more
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAS1R2, taste 1 receptor member 2
  • Synonyms
    GPR71, T1R2, TR2
  • Links
    NCBI Gene ID: 80834
    UniProt: Q8TE23

  • Chr Location
    1p36.13; chr1:18839599-18859660 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    1
  • cDNA Data
    1
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83770 NCBI Gene Model | MGI Sequence Detail 16743 C57BL/6J ±  kb
    transcript NM_031873 RefSeq | MGI Sequence Detail 3060 ZRU/MplStud  
    polypeptide Q925I4 UniProt | EBI | MGI Sequence Detail 843 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      Genomic 3
      cDNA 1
      Primer pair 1
      Antibodies 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1340027
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:53048 Hoon MA, et al., Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell. 1999 Feb 19;96(4):541-51
    • Latest
      J:376742 Mai L, et al., Nutritional regulation of metabolism-dependent and-independent glucosensing in the mammalian taste system. Mol Metab. 2025 Nov 11;103:102280
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory