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Hcar2 Gene Detail
Summary
  • Symbol
    Hcar2
  • Name
    hydroxycarboxylic acid receptor 2
  • Synonyms
    Gpr109a, Gpr109b, HM74, Niacr1, Pumag, PUMA-G
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933383
    NCBI Gene: 80885
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124001633-124003562 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.24 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933383
 protein coding gene Chr5:124001633-124003579 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030080
 protein coding gene Chr5:127625731-127627660 (-)
A/J MGP_AJ_G0030045
 protein coding gene Chr5:122332166-122334093 (-)
AKR/J MGP_AKRJ_G0029981
 protein coding gene Chr5:126267740-126269667 (-)
BALB/cJ MGP_BALBcJ_G0030056
 protein coding gene Chr5:123661341-123663273 (-)
C3H/HeJ MGP_C3HHeJ_G0029773
 protein coding gene Chr5:126877210-126879137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030509
 protein coding gene Chr5:132576541-132578467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027735
 protein coding gene Chr5:116872082-116874011 (-)
CAST/EiJ MGP_CASTEiJ_G0029182
 protein coding gene Chr5:125983763-125987282 (-)
CBA/J MGP_CBAJ_G0029743
 protein coding gene Chr5:137773224-137775150 (-)
DBA/2J MGP_DBA2J_G0029893
 protein coding gene Chr5:122351214-122353141 (-)
FVB/NJ MGP_FVBNJ_G0029849
 protein coding gene Chr5:121380324-121382250 (-)
LP/J MGP_LPJ_G0029982
 protein coding gene Chr5:128173105-128175032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029880
 protein coding gene Chr5:141391181-141393107 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030550
 protein coding gene Chr5:125871820-125873748 (-)
PWK/PhJ MGP_PWKPhJ_G0028896
 protein coding gene Chr5:121161791-121163806 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028733
 protein coding gene Chr5:123535958-123537886 (-)
WSB/EiJ MGP_WSBEiJ_G0029257
 protein coding gene Chr5:126560547-126562474 (-)



Homology
more
  • Human Ortholog
    HCAR2, hydroxycarboxylic acid receptor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCAR2, hydroxycarboxylic acid receptor 2
  • Synonyms
    GPR109A, HCA2, HM74a, HM74b, NIACR1, Puma-g, PUMAG
  • Links
    NCBI Gene ID: 338442
    neXtProt AC: NX_Q8TDS4
    UniProt: Q8TDS4

  • Chr Location
    12q24.31; chr12:122701293-122703357 (-)  GRCh38
  • Human Ortholog
    HCAR3, hydroxycarboxylic acid receptor 3
  • Synonyms
    GPR109B, HCA3, HM74, Puma-g, PUMAG
  • Links
    NCBI Gene ID: 8843
    neXtProt AC: NX_P49019
    UniProt: P49019

  • Chr Location
    12q24.31; chr12:122714756-122716811 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene showed impaired reductions of free fatty acid (FFA) and triglyceride plasma levels in response to nicotinic acid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    50
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045502 Ensembl Gene Model | MGI Sequence Detail 1930 C57BL/6J ±  kb
    transcript ENSMUST00000057145 Ensembl | MGI Sequence Detail 1930 Not Applicable  
    polypeptide ENSMUSP00000054104 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 59
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346135 Li YJ, et al., Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose. Front Cell Dev Biol. 2023;11:1182570
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory