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Trim23 Gene Detail
Summary
  • Symbol
    Trim23
  • Name
    tripartite motif-containing 23
  • Synonyms
    6330516O20Rik, Arfd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933161
    NCBI Gene: 81003
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:104315305-104339880 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 56.35 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933161
 protein coding gene Chr13:104315187-104339983 (+)
129S1/SvImJ ENSMUSG00200008186
 protein coding gene Chr13:98729237-98753780 (+)
A/J ENSMUSG00195029031
 protein coding gene Chr13:99322320-99346897 (+)
AKR/J ENSMUSG00220026061
 protein coding gene Chr13:97743448-97768028 (+)
BALB/cJ ENSMUSG00180036300
 protein coding gene Chr13:99876695-99901239 (+)
C3H/HeJ ENSMUSG00175016920
 protein coding gene Chr13:99959953-99984251 (+)
C57BL/6NJ ENSMUSG00215029066
 protein coding gene Chr13:99962430-99987005 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018860
 protein coding gene Chr13:97751472-97777827 (+)
CAST/EiJ ENSTCUG00005011329
 protein coding gene Chr13:99085070-99109607 (+)
CBA/J ENSMUSG00210010806
 protein coding gene Chr13:99280908-99305206 (+)
DBA/2J ENSMUSG00185026468
 protein coding gene Chr13:103039321-103063896 (+)
FVB/NJ ENSMUSG00205018189
 protein coding gene Chr13:98727850-98752394 (+)
JF1/MsJ ENSUMUG00000010280
 protein coding gene Chr13:102634470-102658775 (+)
LP/J ENSMUSG00230005791
 protein coding gene Chr13:113198963-113223504 (+)
NOD/ShiLtJ ENSMUSG00190037335
 protein coding gene Chr13:99637444-99662021 (+)
NZO/HlLtJ ENSMUSG00225037196
 protein coding gene Chr13:105531233-105557793 (+)
PWK/PhJ ENSLUMG00010025055
 protein coding gene Chr13:98683129-98707404 (+)
SPRET/EiJ ENSMSPG00010008847
 protein coding gene Chr13:100092012-100116332 (+)
WSB/EiJ ENSIUOG00005030880
 protein coding gene Chr13:98721932-98746481 (+)



Homology
more
  • Human Ortholog
    TRIM23, tripartite motif containing 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM23, tripartite motif containing 23
  • Synonyms
    ARD1, ARFD1, RNF46
  • Links
    NCBI Gene ID: 373
    UniProt: P36406

  • Chr Location
    5q12.3; chr5:65589690-65625975 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit mild myopathy with sarcotubular myopathy, decreased fertility, and decreased axon diameter. Mice homozygous for a null allele display increased heart rate and increased chemical nociceptive threshold.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    15
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021712 Ensembl Gene Model | MGI Sequence Detail 24576 C57BL/6J ±  kb
    transcript ENSMUST00000022225 Ensembl | MGI Sequence Detail 3416 Not Applicable  
    polypeptide ENSMUSP00000022225 Ensembl | MGI Sequence Detail 574 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 16

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923425, MGI:2145241
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:306292 Cao X, et al., Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels. J Biol Chem. 2021 May 3;:100738
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory