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Mettl27 Gene Detail
Summary
  • Symbol
    Mettl27
  • Name
    methyltransferase like 27
  • Synonyms
    MGC:8159, Wbscr27
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933146
    NCBI Gene: 79565
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134961222-134971491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933146
 protein coding gene Chr5:134961158-134971491 (+)
129S1/SvImJ ENSMUSG00200042634
 protein coding gene Chr5:128743604-128753835 (+)
A/J ENSMUSG00195048641
 protein coding gene Chr5:128250057-128260291 (+)
AKR/J ENSMUSG00220048493
 protein coding gene Chr5:127737470-127747703 (+)
BALB/cJ ENSMUSG00180035645
 protein coding gene Chr5:128354815-128365046 (+)
C3H/HeJ ENSMUSG00175034700
 protein coding gene Chr5:130280969-130291200 (+)
C57BL/6NJ ENSMUSG00215044867
 protein coding gene Chr5:128399910-128410143 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005009427
 protein coding gene Chr5:127635182-127644923 (+)
CBA/J ENSMUSG00210007353
 protein coding gene Chr5:129098671-129108902 (+)
DBA/2J ENSMUSG00185052689
 protein coding gene Chr5:132113860-132124091 (+)
FVB/NJ ENSMUSG00205048430
 protein coding gene Chr5:128001774-128012008 (+)
JF1/MsJ ENSUMUG00000049584
 protein coding gene Chr5:135013388-135023152 (+)
LP/J ENSMUSG00230044975
 protein coding gene Chr5:136229453-136239684 (+)
NOD/ShiLtJ ENSMUSG00190026495
 protein coding gene Chr5:128055308-128065539 (+)
NZO/HlLtJ ENSMUSG00225022658
 protein coding gene Chr5:143909187-143919418 (+)
PWK/PhJ ENSLUMG00010013470
 protein coding gene Chr5:126860867-126869610 (+)
SPRET/EiJ ENSMSPG00010030919
 protein coding gene Chr5:130269891-130278292 (+)
WSB/EiJ ENSIUOG00005033961
 protein coding gene Chr5:130702114-130712345 (+)



Homology
more
  • Human Ortholog
    METTL27, methyltransferase like 27
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL27, methyltransferase like 27
  • Synonyms
    WBSCR27
  • Links
    NCBI Gene ID: 155368
    UniProt: Q8N6F8

  • Chr Location
    7q11.23; chr7:73834012-73842539 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotype references
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040557 Ensembl Gene Model | MGI Sequence Detail 10270 C57BL/6J ±  kb
transcript ENSMUST00000047196 Ensembl | MGI Sequence Detail 2808 Not Applicable  
polypeptide ENSMUSP00000039080 Ensembl | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • PDB
    7QCB, 7QCC
  • InterPro Domains
    IPR041698 Methyltransferase domain 25
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141200, MGI:5883608
References
more
  • Summaries
    All 38
    Diseases 2
    Phenotypes 17
  • Earliest
    J:73830 DeSilva U, et al., Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res. 2002 Jan;12(1):3-15
  • Latest
    J:373971 Gutzen R, et al., A modular and adaptable analysis pipeline to compare slow cerebral rhythms across heterogeneous datasets. Cell Rep Methods. 2024 Jan 22;4(1):100681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory