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Cstf2t Gene Detail
Summary
  • Symbol
    Cstf2t
  • Name
    cleavage stimulation factor, 3' pre-RNA subunit 2, tau
  • Synonyms
    64kDa, tCstF-64
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932622
    NCBI Gene: 83410
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:31060241-31063992 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 25.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932622
 protein coding gene Chr19:31060237-31064469 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025036
 protein coding gene Chr19:29652768-29656527 (+)
A/J MGP_AJ_G0025013
 protein coding gene Chr19:28164816-28168565 (+)
AKR/J MGP_AKRJ_G0024981
 protein coding gene Chr19:29160886-29164635 (+)
BALB/cJ MGP_BALBcJ_G0025012
 protein coding gene Chr19:28215826-28219575 (+)
C3H/HeJ MGP_C3HHeJ_G0024768
 protein coding gene Chr19:29149324-29153073 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025453
 protein coding gene Chr19:30468867-30472616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022872
 protein coding gene Chr19:28121180-28124899 (+)
CAST/EiJ MGP_CASTEiJ_G0024238
 protein coding gene Chr19:29021792-29025554 (+)
CBA/J MGP_CBAJ_G0024746
 protein coding gene Chr19:31910527-31914276 (+)
DBA/2J MGP_DBA2J_G0024878
 protein coding gene Chr19:28102576-28106325 (+)
FVB/NJ MGP_FVBNJ_G0024840
 protein coding gene Chr19:27932392-27936151 (+)
LP/J MGP_LPJ_G0024963
 protein coding gene Chr19:29655222-29658981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024867
 protein coding gene Chr19:31803617-31807366 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025508
 protein coding gene Chr19:29183542-29187291 (+)
PWK/PhJ MGP_PWKPhJ_G0023986
 protein coding gene Chr19:27784406-27788136 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023790
 protein coding gene Chr19:28531211-28534783 (+)
WSB/EiJ MGP_WSBEiJ_G0024305
 protein coding gene Chr19:29249470-29253219 (+)



Homology
more
  • Human Ortholog
    CSTF2T, cleavage stimulation factor subunit 2 tau variant
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSTF2T, cleavage stimulation factor subunit 2 tau variant
  • Synonyms
    CstF-64T
  • Links
    NCBI Gene ID: 23283
    neXtProt AC: NX_Q9H0L4
    UniProt: Q9H0L4

  • Chr Location
    10q21.1; chr10:51695486-51699595 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a targeted null allele are infertile due to low sperm counts, significant developmental defects in spermiogenesis, and variable abnormalities in epididymal sperm morphology and motility consistent with oligoasthenoteratozoospermia. Homozygous null females are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    4
  • cDNA Data
    97
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83410 NCBI Gene Model | MGI Sequence Detail 3752 C57BL/6J ±  kb
    transcript NM_031249 RefSeq | MGI Sequence Detail 3764 C57BL/6  
    polypeptide Q8C7E9 UniProt | EBI | MGI Sequence Detail 632 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005977 cleavage stimulation factor subunit 2 tau variant
      (term hierarchy)
    • InterPro Domains
      IPR025742 Cleavage stimulation factor subunit 2, hinge domain
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
      IPR026896 Transcription termination and cleavage factor, C-terminal domain
      IPR038192 Transcription termination and cleavage factor, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 97
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147783
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:316534 Grozdanov PN, et al., Cstf2t Regulates expression of histones and histone-like proteins in male germ cells. Andrology. 2018 Jul;6(4):605-615
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory