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Siglece Gene Detail
Summary
  • Symbol
    Siglece
  • Name
    sialic acid binding Ig-like lectin E
  • Synonyms
    mSiglec-E, Siglec5, Siglecl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932475
    NCBI Gene: 83382
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43300494-43309585 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932475
 protein coding gene Chr7:43300494-43309585 (-)
129S1/SvImJ ENSMUSG00200028015
 protein coding gene Chr7:30886262-30895350 (-)
A/J ENSMUSG00195047161
 protein coding gene Chr7:34926407-34935501 (-)
AKR/J ENSMUSG00220052447
 protein coding gene Chr7:29224490-29233577 (-)
BALB/cJ ENSMUSG00180037457
 protein coding gene Chr7:31801892-31810985 (-)
C3H/HeJ ENSMUSG00175037869
 protein coding gene Chr7:32322212-32331299 (-)
C57BL/6NJ ENSMUSG00215043603
 protein coding gene Chr7:31592019-31601111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029632
 protein coding gene Chr7:44908775-44917911 (-)
CAST/EiJ ENSTCUG00005045231
 protein coding gene Chr7:35319100-35328453 (-)
CBA/J ENSMUSG00210047247
 protein coding gene Chr7:32698944-32708040 (-)
DBA/2J ENSMUSG00185035669
 protein coding gene Chr7:36571865-36580959 (-)
FVB/NJ ENSMUSG00205037849
 protein coding gene Chr7:32244159-32253254 (-)
JF1/MsJ ENSUMUG00000045054
 protein coding gene Chr7:41058872-41067971 (-)
LP/J ENSMUSG00230047133
 protein coding gene Chr7:42007259-42016340 (-)
NOD/ShiLtJ ENSMUSG00190045940
 protein coding gene Chr7:32565854-32574944 (-)
NZO/HlLtJ ENSMUSG00225014088
 protein coding gene Chr7:40217821-40226911 (-)
PWK/PhJ ENSLUMG00010037167
 protein coding gene Chr7:31485516-31494603 (-)
SPRET/EiJ ENSMSPG00010039927
 protein coding gene Chr7:31287067-31295872 (-)
WSB/EiJ ENSIUOG00005029230
 protein coding gene Chr7:33136434-33145535 (-)



Homology
more
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIGLEC12, sialic acid binding Ig like lectin 12
  • Synonyms
    S2V, SIGLECL1, Siglec-XII, SLG
  • Links
    NCBI Gene ID: 89858
    UniProt: Q96PQ1

  • Chr Location
    19q13.41; chr19:51491227-51501800 (-)  GRCh38
  • Human Ortholog
    SIGLEC7, sialic acid binding Ig like lectin 7
  • Synonyms
    AIRM-1, AIRM1, CD328, CDw328, D-siglec, p75, p75/AIRM1, QA79, SIGLEC19P, SIGLEC-7, SIGLECP2
  • Links
    NCBI Gene ID: 27036
    UniProt: Q9Y286

  • Chr Location
    19q13.41; chr19:51142288-51153658 (+)  GRCh38
  • Human Ortholog
    SIGLEC8, sialic acid binding Ig like lectin 8
  • Synonyms
    SAF2, SIGLEC-8, SIGLEC8L
  • Links
    NCBI Gene ID: 27181
    UniProt: Q9NYZ4

  • Chr Location
    19q13.41; chr19:51450847-51458469 (-)  GRCh38
  • Human Ortholog
    SIGLEC9, sialic acid binding Ig like lectin 9
  • Synonyms
    CD329, CDw329, FOAP-9, OBBP-LIKE, siglec-9
  • Links
    NCBI Gene ID: 27180
    UniProt: Q9Y336

  • Chr Location
    19q13.41; chr19:51119778-51140470 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele or a knock-in allele that destroys the sialic acid binding site exhibit increased neutrophil and macrophage recruitment in an LPS-induced model of acute lung ariway inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    607
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83382 NCBI Gene Model | MGI Sequence Detail 9092 C57BL/6J ±  kb
transcript NM_031181 RefSeq | MGI Sequence Detail 1849 Not Specified  
polypeptide Q91Y57 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003599 Immunoglobulin domain subtype
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR003598 Immunoglobulin subtype 2
    IPR013106 Immunoglobulin V-set domain
    IPR051036 Sialic acid-binding Ig-like lectin
  • GlyGen
    Q91Y57 10 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 63
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 29
  • Earliest
    J:67541 Yu Z, et al., mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J. 2001 Feb 1;353(Pt 3):483-92
  • Latest
    J:379642 Xu Z, et al., Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation. Adv Sci (Weinh). 2026 Jan;13(5):e12681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory