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Btnl6 Gene Detail
Summary
  • Symbol
    Btnl6
  • Name
    butyrophilin-like 6
  • Synonyms
    Gm6519, NG13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932038
    NCBI Gene: 624681
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34726778-34736326 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932038
 protein coding gene Chr17:34726778-34737750 (-)
129S1/SvImJ ENSMUSG00200049044
 protein coding gene Chr17:30430075-30439488 (-)
A/J ENSMUSG00195042593
 protein coding gene Chr17:31331041-31340446 (-)
AKR/J ENSMUSG00220050982
 protein coding gene Chr17:30358671-30368074 (-)
BALB/cJ no annotation
C3H/HeJ ENSMUSG00175032342
 protein coding gene Chr17:30244798-30254195 (-)
C57BL/6NJ ENSMUSG00215046700
 protein coding gene Chr17:30270239-30279652 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021459
 protein coding gene Chr17:31297690-31309452 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210047275
 protein coding gene Chr17:30066895-30076304 (-)
DBA/2J no annotation
FVB/NJ ENSMUSG00205052858
 protein coding gene Chr17:30588399-30597785 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230053652
 protein coding gene Chr17:33828358-33837771 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010039646
 protein coding gene Chr17:30990332-30999717 (-)
WSB/EiJ ENSIUOG00005048445
 protein coding gene Chr17:30917875-30927257 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased CD4-positive, gamma-delta intraepithelial T cells in the gut.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000092618 Ensembl Gene Model | MGI Sequence Detail 9549 C57BL/6J ±  kb
transcript ENSMUST00000075483 Ensembl | MGI Sequence Detail 1620 Not Applicable  
polypeptide ENSMUSP00000074927 Ensembl | MGI Sequence Detail 539 Not Applicable  
For the selected sequence
Protein
Information
less
Other
Accession IDs
less
MGI:3645183
References
more
  • Summaries
    All 16
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:61935 Stammers M, et al., BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. Immunogenetics. 2000 Apr;51(4-5):373-82
  • Latest
    J:291989 Jandke A, et al., Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial gammadelta T cell compartments. Nat Commun. 2020 Jul 28;11(1):3769
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory