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Dnaja2 Gene Detail
Summary
  • Symbol
    Dnaja2
  • Name
    DnaJ heat shock protein family (Hsp40) member A2
  • Synonyms
    1500017M13Rik, 2010206B19Rik, DNJ3, HIRIP4, mDj3, PRO3015
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931882
    NCBI Gene: 56445
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:86264262-86281973 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.61 cM, cytoband C4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    457 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931882
 protein coding gene Chr8:86264262-86281990 (-)
129S1/SvImJ ENSMUSG00200016540
 protein coding gene Chr8:80611220-80628899 (-)
A/J ENSMUSG00195026271
 protein coding gene Chr8:80979318-80996982 (-)
AKR/J ENSMUSG00220033458
 protein coding gene Chr8:81010224-81027899 (-)
BALB/cJ ENSMUSG00180018685
 protein coding gene Chr8:80814635-80832313 (-)
C3H/HeJ ENSMUSG00175025972
 protein coding gene Chr8:80914973-80932637 (-)
C57BL/6NJ ENSMUSG00215011152
 protein coding gene Chr8:80530971-80548684 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031340
 protein coding gene Chr8:76866797-76883632 (-)
CAST/EiJ ENSTCUG00005034671
 protein coding gene Chr8:80410267-80428063 (-)
CBA/J ENSMUSG00210032931
 protein coding gene Chr8:80902087-80919751 (-)
DBA/2J ENSMUSG00185033014
 protein coding gene Chr8:87010674-87028338 (-)
FVB/NJ ENSMUSG00205036891
 protein coding gene Chr8:79957926-79975590 (-)
JF1/MsJ ENSUMUG00000011181
 protein coding gene Chr8:89337369-89355111 (-)
LP/J ENSMUSG00230030851
 protein coding gene Chr8:90608154-90625831 (-)
NOD/ShiLtJ ENSMUSG00190014507
 protein coding gene Chr8:80986031-81003741 (-)
NZO/HlLtJ ENSMUSG00225039774
 protein coding gene Chr8:94021903-94039614 (-)
PWK/PhJ ENSLUMG00010025699
 protein coding gene Chr8:80664991-80682713 (-)
SPRET/EiJ ENSMSPG00010026456
 protein coding gene Chr8:82571904-82590252 (-)
WSB/EiJ ENSIUOG00005019108
 protein coding gene Chr8:81704976-81722668 (-)



Homology
more
  • Human Ortholog
    DNAJA2, DnaJ heat shock protein family (Hsp40) member A2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAJA2, DnaJ heat shock protein family (Hsp40) member A2
  • Synonyms
    CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2
  • Links
    NCBI Gene ID: 10294
    UniProt: O60884

  • Chr Location
    16q11.2; chr16:46955362-46973704 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    231
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031701 Ensembl Gene Model | MGI Sequence Detail 17712 C57BL/6J ±  kb
    transcript ENSMUST00000034138 Ensembl | MGI Sequence Detail 2919 Not Applicable  
    polypeptide ENSMUSP00000034138 Ensembl | MGI Sequence Detail 412 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 231
      cDNA 231

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917245, MGI:1923592
    References
    more
    • Summaries
      All 76
      Gene Ontology 6
      Phenotypes 43
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:375696 Qin Y, et al., Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis. Nat Commun. 2025 Nov 13;16(1):9973
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory