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Rhoj Gene Detail
Summary
  • Symbol
    Rhoj
  • Name
    ras homolog family member J
  • Synonyms
    1110005O19Rik, Arhj, TC10L, TCL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931551
    NCBI Gene: 80837
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:75355096-75448230 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 32.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    784 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931551
 protein coding gene Chr12:75355087-75448230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019846
 protein coding gene Chr12:75320333-75408518 (+)
A/J MGP_AJ_G0019804
 protein coding gene Chr12:72503738-72589002 (+)
AKR/J MGP_AKRJ_G0019779
 protein coding gene Chr12:74697698-74785681 (+)
BALB/cJ MGP_BALBcJ_G0019783
 protein coding gene Chr12:72968901-73059578 (+)
C3H/HeJ MGP_C3HHeJ_G0019589
 protein coding gene Chr12:75160081-75250558 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020235
 protein coding gene Chr12:77676162-77773874 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017853
 protein coding gene Chr12:69850207-69937624 (+)
CAST/EiJ MGP_CASTEiJ_G0019140
 protein coding gene Chr12:69925990-70021441 (+)
CBA/J MGP_CBAJ_G0019559
 protein coding gene Chr12:80663307-80762327 (+)
DBA/2J MGP_DBA2J_G0019675
 protein coding gene Chr12:72370511-72456375 (+)
FVB/NJ MGP_FVBNJ_G0019662
 protein coding gene Chr12:71191744-71275365 (+)
LP/J MGP_LPJ_G0019747
 protein coding gene Chr12:75343125-75428691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019701
 protein coding gene Chr12:83738133-83833552 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020271
 protein coding gene Chr12:74170155-74259317 (+)
PWK/PhJ MGP_PWKPhJ_G0018906
 protein coding gene Chr12:66708450-66799349 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018700
 protein coding gene Chr12:68652534-68744075 (+)
WSB/EiJ MGP_WSBEiJ_G0019192
 protein coding gene Chr12:74762176-74855904 (+)



Homology
more
  • Human Ortholog
    RHOJ, ras homolog family member J
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOJ, ras homolog family member J
  • Synonyms
    ARHJ, RASL7B, TC10B, TCL
  • Links
    NCBI Gene ID: 57381
    neXtProt AC: NX_Q9H4E5
    UniProt: Q9H4E5

  • Chr Location
    14q23.2; chr14:63204114-63293508 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    5 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a slight delay in radial growth in the retina and empty basement membrane sleeves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1048
  • Tissues
    54
  • cDNA Data
    66
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046768 Ensembl Gene Model | MGI Sequence Detail 93135 C57BL/6J ±  kb
    transcript ENSMUST00000055390 Ensembl | MGI Sequence Detail 2350 Not Applicable  
    polypeptide ENSMUSP00000059498 Ensembl | MGI Sequence Detail 214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 66
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914157, MGI:2145016
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 10
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65771 Vignal E, et al., Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem. 2000 Nov 17;275(46):36457-64
    • Latest
      J:340000 Debaugnies M, et al., RHOJ controls EMT-associated resistance to chemotherapy. Nature. 2023 Apr;616(7955):168-175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory