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H1f4 Gene Detail
Summary
  • Symbol
    H1f4
  • Name
    H1.4 linker histone, cluster member
  • Synonyms
    H1-4, H1e, H1f4, H1s-4, H1var2, Hist1h1e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931527
    NCBI Gene: 50709
  • Member of
    Hist1 cluster
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:23805760-23806541 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 9.83 cM, cytoband A3.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931527
protein coding gene Chr13:23804612-23806541 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020354
protein coding gene Chr13:21053638-21056012 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0020285
protein coding gene Chr13:20923232-20925582 (-)
BALB/cJ MGP_BALBcJ_G0020302
protein coding gene Chr13:20668931-20669753 (-)
C3H/HeJ MGP_C3HHeJ_G0020107
protein coding gene Chr13:20991228-20992514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020740
protein coding gene Chr13:21835773-21837616 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018326
protein coding gene Chr13:19461791-19462535 (-)
CAST/EiJ MGP_CASTEiJ_G0019624
protein coding gene Chr13:20678441-20679188 (-)
CBA/J MGP_CBAJ_G0020058
protein coding gene Chr13:22672484-22678742 (-)
DBA/2J MGP_DBA2J_G0020185
protein coding gene Chr13:20208059-20208806 (-)
FVB/NJ MGP_FVBNJ_G0020170
protein coding gene Chr13:19854027-19854774 (-)
LP/J MGP_LPJ_G0020258
protein coding gene Chr13:21370396-21372350 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020198
protein coding gene Chr13:22974653-22976749 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020779
protein coding gene Chr13:20776159-20776906 (-)
PWK/PhJ MGP_PWKPhJ_G0019379
protein coding gene Chr13:20234603-20235706 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019214
protein coding gene Chr13:20043313-20045298 (+)
WSB/EiJ MGP_WSBEiJ_G0019683
protein coding gene Chr13:20908018-20909664 (-)



Homology
more
  • Human Ortholog
    H1-4, H1.4 linker histone, cluster member
  • Vertebrate Orthologs
    11
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H1-4, H1.4 linker histone, cluster member
  • Synonyms
    dJ221C16.5, H1.4, H1E, H1F4, H1s-4, HIST1H1E, RMNS
  • Links
    NCBI Gene ID: 3008
    neXtProt AC: NX_P10412
    UniProt: P10412

  • Chr Location
    6p22.2; chr6:26156329-26157115 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving H1f4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygotes for targeted null mutations are normal, but Hist1h1e/Hist1h1c double knockout males are significantly smaller than normal. The Hist1h1e/Hist1h1d/Hist1h1e triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50709 NCBI Gene Model | MGI Sequence Detail 782 C57BL/6J ±  kb
transcript NM_015787 RefSeq | MGI Sequence Detail 782 C57BL/6  
polypeptide P43274 UniProt | EBI | MGI Sequence Detail 219 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    Genomic 1
    cDNA 2
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:249818 Izzo A, et al., Dynamic changes in H1 subtype composition during epigenetic reprogramming. J Cell Biol. 2017 Aug 9;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory