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Marchf7 Gene Detail
Summary
  • Symbol
    Marchf7
  • Name
    membrane associated ring-CH-type finger 7
  • Synonyms
    Axot, Gtrgeo17, March7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931053
    NCBI Gene: 57438
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:60040086-60079555 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 34.46 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    794 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931053
 protein coding gene Chr2:60040086-60081020 (+)
129S1/SvImJ ENSMUSG00200002513
 protein coding gene Chr2:57109096-57148402 (+)
A/J ENSMUSG00195004820
 protein coding gene Chr2:57226434-57265757 (+)
AKR/J ENSMUSG00220007009
 protein coding gene Chr2:57328399-57367724 (+)
BALB/cJ ENSMUSG00180019429
 protein coding gene Chr2:57182686-57222017 (+)
C3H/HeJ ENSMUSG00175013567
 protein coding gene Chr2:57251471-57290794 (+)
C57BL/6NJ ENSMUSG00215007042
 protein coding gene Chr2:57236095-57275423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023581
 protein coding gene Chr2:55088585-55110243 (+)
CAST/EiJ ENSTCUG00005022072
 protein coding gene Chr2:56584268-56623775 (+)
CBA/J ENSMUSG00210033555
 protein coding gene Chr2:57270634-57309950 (+)
DBA/2J ENSMUSG00185008145
 protein coding gene Chr2:57126713-57166055 (+)
FVB/NJ ENSMUSG00205017151
 protein coding gene Chr2:56767334-56806662 (+)
JF1/MsJ ENSUMUG00000017963
 protein coding gene Chr2:56821093-56860176 (+)
LP/J ENSMUSG00230001208
 protein coding gene Chr2:58992843-59032146 (+)
NOD/ShiLtJ ENSMUSG00190026566
 protein coding gene Chr2:57215975-57255303 (+)
NZO/HlLtJ ENSMUSG00225000623
 protein coding gene Chr2:66715336-66754658 (+)
PWK/PhJ ENSLUMG00010005319
 protein coding gene Chr2:56984461-57023586 (+)
SPRET/EiJ ENSMSPG00010011731
 protein coding gene Chr2:58147413-58184621 (+)
WSB/EiJ ENSIUOG00005027212
 protein coding gene Chr2:57254487-57293969 (+)



Homology
more
  • Human Ortholog
    MARCHF7, membrane associated ring-CH-type finger 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MARCHF7, membrane associated ring-CH-type finger 7
  • Synonyms
    AXO, AXOT, MARCH7, MARCH-VII, RNF177
  • Links
    NCBI Gene ID: 64844
    UniProt: Q9H992

  • Chr Location
    2q24.2; chr2:159712001-159771027 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show premature neural degeneration and defective development of the corpus callosum. Both T cell proliferation and T cell-derived leukaemia inhibitory factor are increased.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    5
  • cDNA Data
    215
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57438 NCBI Gene Model | MGI Sequence Detail 39470 C57BL/6J ±  kb
    transcript NM_001418492 RefSeq | MGI Sequence Detail 4177 C57BL/6  
    polypeptide Q9WV66 UniProt | EBI | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 216
      cDNA 215
      Primer pair 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:6368855, MGI:894656
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
    • Latest
      J:380828 Al Adhami H, et al., Systematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells. Nucleic Acids Res. 2023 Apr 24;51(7):3130-3149
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory