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Stx1b Gene Detail
Summary
  • Symbol
    Stx1b
  • Name
    syntaxin 1B
  • Synonyms
    Stx1b2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930705
    NCBI Gene: 56216
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127403072-127423703 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930705
 protein coding gene Chr7:127403072-127423721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033056
 protein coding gene Chr7:132178443-132199265 (-)
A/J MGP_AJ_G0033039
 protein coding gene Chr7:128643274-128665337 (-)
AKR/J MGP_AKRJ_G0032971
 protein coding gene Chr7:131969835-131992585 (-)
BALB/cJ MGP_BALBcJ_G0033040
 protein coding gene Chr7:128297396-128318215 (-)
C3H/HeJ MGP_C3HHeJ_G0032754
 protein coding gene Chr7:131872644-131892844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033549
 protein coding gene Chr7:137328714-137349567 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030522
 protein coding gene Chr7:129845310-129863973 (-)
CAST/EiJ MGP_CASTEiJ_G0032083
 protein coding gene Chr7:123669278-123690355 (-)
CBA/J MGP_CBAJ_G0032727
 protein coding gene Chr7:141976649-142009216 (-)
DBA/2J MGP_DBA2J_G0032879
 protein coding gene Chr7:126624793-126645934 (-)
FVB/NJ MGP_FVBNJ_G0032832
 protein coding gene Chr7:126480105-126504499 (-)
LP/J MGP_LPJ_G0032973
 protein coding gene Chr7:133653852-133674281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032864
 protein coding gene Chr7:143061208-143085545 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033569
 protein coding gene Chr7:130962153-130985218 (-)
PWK/PhJ MGP_PWKPhJ_G0031790
 protein coding gene Chr7:119636615-119658456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031636
 protein coding gene Chr7:117766264-117787417 (-)
WSB/EiJ MGP_WSBEiJ_G0032195
 protein coding gene Chr7:131927056-131952426 (-)



Homology
more
  • Human Ortholog
    STX1B, syntaxin 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STX1B, syntaxin 1B
  • Synonyms
    GEFSP9, STX1B1, STX1B2
  • Links
    NCBI Gene ID: 112755
    neXtProt AC: NX_P61266
    UniProt: P61266

  • Chr Location
    16p11.2; chr16:30989256-31010638 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STX1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    9
  • cDNA Data
    4
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56216 NCBI Gene Model | MGI Sequence Detail 20632 C57BL/6J ±  kb
    transcript NM_024414 RefSeq | MGI Sequence Detail 1574 Not Specified  
    polypeptide P61264 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 21
      Gene Ontology 14
      Phenotypes 17
    • Earliest
      J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
    • Latest
      J:326473 Vardar G, et al., Syntaxin-1A modulates vesicle fusion in mammalian neurons via juxtamembrane domain dependent palmitoylation of its transmembrane domain. Elife. 2022 May 31;11:e78182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory