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Stx1b Gene Detail
Summary
  • Symbol
    Stx1b
  • Name
    syntaxin 1B
  • Synonyms
    Stx1b2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930705
    NCBI Gene: 56216
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127403072-127423703 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930705
 protein coding gene Chr7:127403072-127423721 (-)
129S1/SvImJ ENSMUSG00200022317
 protein coding gene Chr7:113916082-113936735 (-)
A/J ENSMUSG00195035785
 protein coding gene Chr7:118417795-118438469 (-)
AKR/J ENSMUSG00220015680
 protein coding gene Chr7:111864754-111885433 (-)
BALB/cJ ENSMUSG00180011245
 protein coding gene Chr7:115105597-115126272 (-)
C3H/HeJ ENSMUSG00175016205
 protein coding gene Chr7:115832490-115853160 (-)
C57BL/6NJ ENSMUSG00215007664
 protein coding gene Chr7:115112802-115133453 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030522
 protein coding gene Chr7:129845310-129863973 (-)
CAST/EiJ ENSTCUG00005045889
 protein coding gene Chr7:118359110-118379376 (-)
CBA/J ENSMUSG00210022962
 protein coding gene Chr7:115593831-115614480 (-)
DBA/2J ENSMUSG00185041551
 protein coding gene Chr7:119906657-119927311 (-)
FVB/NJ ENSMUSG00205016875
 protein coding gene Chr7:115549652-115570309 (-)
JF1/MsJ ENSUMUG00000009750
 protein coding gene Chr7:124957640-124978210 (-)
LP/J ENSMUSG00230052148
 protein coding gene Chr7:126015998-126036647 (-)
NOD/ShiLtJ ENSMUSG00190016822
 protein coding gene Chr7:115744067-115764726 (-)
NZO/HlLtJ ENSMUSG00225011174
 protein coding gene Chr7:124245749-124266421 (-)
PWK/PhJ ENSLUMG00010033573
 protein coding gene Chr7:114094300-114114870 (-)
SPRET/EiJ ENSMSPG00010009997
 protein coding gene Chr7:115353687-115374006 (-)
WSB/EiJ ENSIUOG00005029735
 protein coding gene Chr7:116444136-116464785 (-)



Homology
more
  • Human Ortholog
    STX1B, syntaxin 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STX1B, syntaxin 1B
  • Synonyms
    GEFSP9, STX1B1, STX1B2
  • Links
    NCBI Gene ID: 112755
    UniProt: P61266

  • Chr Location
    16p11.2; chr16:30989256-31010672 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STX1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    19
  • cDNA Data
    4
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56216 NCBI Gene Model | MGI Sequence Detail 20632 C57BL/6J ±  kb
    transcript NM_024414 RefSeq | MGI Sequence Detail 1574 Not Specified  
    polypeptide P61264 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4
      Antibodies 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 22
      Gene Ontology 16
      Phenotypes 19
    • Earliest
      J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
    • Latest
      J:368735 Salazar Lazaro A, et al., The stability of the primed pool of synaptic vesicles and the clamping of spontaneous neurotransmitter release rely on the integrity of the C-terminal half of the SNARE domain of syntaxin-1A. Elife. 2024 Mar 21;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory