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Clstn2 Gene Detail
Summary
  • Symbol
    Clstn2
  • Name
    calsyntenin 2
  • Synonyms
    2900042C18Rik, CS2, Cst-2, CSTN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929897
    NCBI Gene: 64085
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:97326448-97915234 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 51.06 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6893 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929897
 protein coding gene Chr9:97326448-97915433 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035151
 protein coding gene Chr9:98716195-99321297 (-)
A/J MGP_AJ_G0035133
 protein coding gene Chr9:95247233-95841893 (-)
AKR/J MGP_AKRJ_G0035064
 protein coding gene Chr9:97564836-98173826 (-)
BALB/cJ MGP_BALBcJ_G0035125
 protein coding gene Chr9:94924960-95519814 (-)
C3H/HeJ MGP_C3HHeJ_G0034835
 protein coding gene Chr9:97980153-98575459 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035645
 protein coding gene Chr9:101530338-102156527 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032545
 protein coding gene Chr9:93040371-93622723 (-)
CAST/EiJ MGP_CASTEiJ_G0034147
 protein coding gene Chr9:97766284-98376290 (-)
CBA/J MGP_CBAJ_G0034803
 protein coding gene Chr9:105058303-105684059 (-)
DBA/2J MGP_DBA2J_G0034965
 protein coding gene Chr9:94759268-95350329 (-)
FVB/NJ MGP_FVBNJ_G0034913
 protein coding gene Chr9:93599444-94187889 (-)
LP/J MGP_LPJ_G0035044
 protein coding gene Chr9:98969631-99575836 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034952
 protein coding gene Chr9:107026124-107639706 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035667
 protein coding gene Chr9:97814417-98418984 (-)
PWK/PhJ MGP_PWKPhJ_G0033854
 protein coding gene Chr9:94960589-95555830 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033689
 protein coding gene Chr9:97851022-98456893 (-)
WSB/EiJ MGP_WSBEiJ_G0034267
 protein coding gene Chr9:97665511-98272306 (-)



Homology
more
  • Human Ortholog
    CLSTN2, calsyntenin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLSTN2, calsyntenin 2
  • Synonyms
    alcagamma, ALC-GAMMA, CDHR13, CS2, CSTN2
  • Links
    NCBI Gene ID: 64084
    neXtProt AC: NX_Q9H4D0
    UniProt: Q9H4D0

  • Chr Location
    3q23; chr3:139935185-140577397 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO mice display deficiency in spatial learning and memory in Morris water and Barnes maze tasks and increased locomotor activity in open field test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    14
  • cDNA Data
    15
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032452 Ensembl Gene Model | MGI Sequence Detail 588787 C57BL/6J ±  kb
transcript ENSMUST00000035027 Ensembl | MGI Sequence Detail 4365 Not Applicable  
polypeptide ENSMUSP00000035027 Ensembl | MGI Sequence Detail 966 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 2
    cDNA 16
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924325, MGI:2143055
References
more
  • Summaries
    All 46
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326661 Xu P, et al., Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory