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Tnmd Gene Detail
Summary
  • Symbol
    Tnmd
  • Name
    tenomodulin
  • Synonyms
    1110017I01Rik, Bricd4, ChM1L, myodulin, TeM, tendin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929885
    NCBI Gene: 64103
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:132751757-132766326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.47 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929885
 protein coding gene ChrX:132751729-132766326 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036056
 protein coding gene ChrX:131001737-131016407 (+)
A/J MGP_AJ_G0036038
 protein coding gene ChrX:130425966-130441011 (+)
AKR/J MGP_AKRJ_G0035957
 protein coding gene ChrX:134597674-134612255 (+)
BALB/cJ MGP_BALBcJ_G0036029
 protein coding gene ChrX:128876108-128890828 (+)
C3H/HeJ MGP_C3HHeJ_G0035733
 protein coding gene ChrX:131085374-131099966 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036551
 protein coding gene ChrX:134866541-134881261 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033379
 protein coding gene ChrX:122634491-122652501 (+)
CAST/EiJ MGP_CASTEiJ_G0035020
 protein coding gene ChrX:111963421-111978280 (+)
CBA/J MGP_CBAJ_G0035710
 protein coding gene ChrX:138902366-138916968 (+)
DBA/2J MGP_DBA2J_G0035863
 protein coding gene ChrX:129767601-129782079 (+)
FVB/NJ MGP_FVBNJ_G0035805
 protein coding gene ChrX:129076114-129090839 (+)
LP/J MGP_LPJ_G0035956
 protein coding gene ChrX:131875222-131889951 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035833
 protein coding gene ChrX:146302999-146317711 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036580
 protein coding gene ChrX:130429692-130444410 (+)
PWK/PhJ MGP_PWKPhJ_G0034712
 protein coding gene ChrX:108917356-108932056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034544
 protein coding gene ChrX:112583223-112602900 (+)
WSB/EiJ MGP_WSBEiJ_G0035157
 protein coding gene ChrX:128815994-128830562 (+)



Homology
more
  • Human Ortholog
    TNMD, tenomodulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNMD, tenomodulin
  • Synonyms
    BRICD4, CHM1L, TEM
  • Links
    NCBI Gene ID: 64102
    neXtProt AC: NX_Q9H2S6
    UniProt: Q9H2S6

  • Chr Location
    Xq22.1; chrX:100584936-100599885 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous females exhibit a decrease in tenocyte proliferation and tendons have a greater variation of collagen fibril calibers exhibiting increased maximal diameters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    976
  • Tissues
    124
  • cDNA Data
    37
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64103 NCBI Gene Model | MGI Sequence Detail 14570 C57BL/6J ±  kb
    transcript NM_022322 RefSeq | MGI Sequence Detail 1338 C57BL/6  
    polypeptide Q9EP64 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 37
      Primer pair 4
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1913410
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 44
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341710 Li H, et al., Increased Ca(2+) signaling through Ca(V) 1.2 induces tendon hypertrophy with increased collagen fibrillogenesis and biomechanical properties. FASEB J. 2023 Jul;37(7):e23007
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory