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Timm22 Gene Detail
Summary
  • Symbol
    Timm22
  • Name
    translocase of inner mitochondrial membrane 22
  • Synonyms
    2610511O07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929742
    NCBI Gene: 56322
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76297778-76307118 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929742
 protein coding gene Chr11:76297751-76307139 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018734
 protein coding gene Chr11:77236957-77247346 (+)
A/J MGP_AJ_G0018700
 protein coding gene Chr11:74352976-74362077 (+)
AKR/J MGP_AKRJ_G0018670
 protein coding gene Chr11:76611374-76620476 (+)
BALB/cJ MGP_BALBcJ_G0018674
 protein coding gene Chr11:74735557-74744659 (+)
C3H/HeJ MGP_C3HHeJ_G0018487
 protein coding gene Chr11:76622062-76631744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019125
 protein coding gene Chr11:79664350-79677743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016760
 protein coding gene Chr11:71352472-71362122 (+)
CAST/EiJ MGP_CASTEiJ_G0018041
 protein coding gene Chr11:77014597-77025730 (+)
CBA/J MGP_CBAJ_G0018457
 protein coding gene Chr11:83144688-83157133 (+)
DBA/2J MGP_DBA2J_G0018566
 protein coding gene Chr11:73949300-73958409 (+)
FVB/NJ MGP_FVBNJ_G0018556
 protein coding gene Chr11:73499650-73508755 (+)
LP/J MGP_LPJ_G0018637
 protein coding gene Chr11:77813390-77823367 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018582
 protein coding gene Chr11:83639328-83651019 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019165
 protein coding gene Chr11:76798946-76808848 (+)
PWK/PhJ MGP_PWKPhJ_G0017812
 protein coding gene Chr11:74674171-74684097 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017603
 protein coding gene Chr11:76371939-76380845 (+)
WSB/EiJ MGP_WSBEiJ_G0018094
 protein coding gene Chr11:76626454-76636136 (+)



Homology
more
  • Human Ortholog
    TIMM22, translocase of inner mitochondrial membrane 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMM22, translocase of inner mitochondrial membrane 22
  • Synonyms
    COXPD43, TEX4, TIM22
  • Links
    NCBI Gene ID: 29928
    neXtProt AC: NX_Q9Y584
    UniProt: Q9Y584

  • Chr Location
    17p13.3; chr17:997129-1003671 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIMM22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    53
  • cDNA Data
    66
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020843 Ensembl Gene Model | MGI Sequence Detail 9341 C57BL/6J ±  kb
    transcript ENSMUST00000021203 Ensembl | MGI Sequence Detail 2817 Not Applicable  
    polypeptide ENSMUSP00000021203 Ensembl | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016346 mitochondrial import inner membrane translocase subunit Tim22
      (term hierarchy)
    • InterPro Domains
      IPR039175 Mitochondrial import inner membrane translocase subunit TIM22
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 67
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914749
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:290315 Cheong A, et al., Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 May 26;147(10):dev188714
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory