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Med20 Gene Detail
Summary
  • Symbol
    Med20
  • Name
    mediator complex subunit 20
  • Synonyms
    1110011O05Rik, 2410115I17Rik, Trfp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929648
    NCBI Gene: 56771
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47922510-47935176 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    503 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929648
 protein coding gene Chr17:47922507-47935343 (+)
129S1/SvImJ ENSMUSG00200027451
 protein coding gene Chr17:43126217-43139061 (+)
A/J ENSMUSG00195021096
 protein coding gene Chr17:44625918-44638757 (+)
AKR/J ENSMUSG00220034150
 protein coding gene Chr17:43625918-43638756 (+)
BALB/cJ ENSMUSG00180021033
 protein coding gene Chr17:44382256-44395093 (+)
C3H/HeJ ENSMUSG00175015432
 protein coding gene Chr17:43689837-43702675 (+)
C57BL/6NJ ENSMUSG00215018611
 protein coding gene Chr17:43246041-43258877 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021704
 protein coding gene Chr17:44316901-44330798 (+)
CAST/EiJ ENSTCUG00005022945
 protein coding gene Chr17:44401992-44414793 (+)
CBA/J ENSMUSG00210029341
 protein coding gene Chr17:43439470-43452308 (+)
DBA/2J ENSMUSG00185029269
 protein coding gene Chr17:46338445-46351283 (+)
FVB/NJ ENSMUSG00205026110
 protein coding gene Chr17:43943007-43955856 (+)
JF1/MsJ ENSUMUG00000015308
 protein coding gene Chr17:45970986-45983763 (+)
LP/J ENSMUSG00230037837
 protein coding gene Chr17:47237780-47250623 (+)
NOD/ShiLtJ ENSMUSG00190017402
 protein coding gene Chr17:43333972-43346821 (+)
NZO/HlLtJ ENSMUSG00225042043
 protein coding gene Chr17:49491077-49503923 (+)
PWK/PhJ ENSLUMG00010034995
 protein coding gene Chr17:43194519-43207281 (+)
SPRET/EiJ ENSMSPG00010029175
 protein coding gene Chr17:43400758-43413489 (+)
WSB/EiJ ENSIUOG00005024032
 protein coding gene Chr17:44291618-44304458 (+)



Homology
more
  • Human Ortholog
    MED20, mediator complex subunit 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MED20, mediator complex subunit 20
  • Synonyms
    PRO0213, SRB2, TRFP
  • Links
    NCBI Gene ID: 9477
    UniProt: Q9H944

  • Chr Location
    6p21.1; chr6:41905354-41921139 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show pre-implantation lethality associated with failure of embryo implantation and ectopic expression of an epiblast marker in the trophectoderm, indicating defects in trophoblast specification. Cultured blastocysts fail to hatch from the zona pellucida with apparent cell death and form atypical outgrowth colonies with no trophectoderm, primitive endoderm or epiblast cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    21
  • cDNA Data
    75
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56771 NCBI Gene Model | MGI Sequence Detail 12667 C57BL/6J ±  kb
    transcript NM_001364926 RefSeq | MGI Sequence Detail 5722 C57BL/6  
    polypeptide Q9R0X0 UniProt | EBI | MGI Sequence Detail 212 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 78
      Primer pair 3
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915846, MGI:1925742, MGI:2146975
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 13
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:379748 Zhu S, et al., The essential role of MED27 in stabilizing the mediator complex for cardiac development and function. Life Sci. 2024 Nov 1;356:123020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory