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Aatf Gene Detail
Summary
  • Symbol
    Aatf
  • Name
    apoptosis antagonizing transcription factor
  • Synonyms
    4933415H02Rik, 5830465M17Rik, Che-1, MGC:35916, Trb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929608
    NCBI Gene: 56321
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:84313681-84404348 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.30 cM, cytoband B5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2082 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929608
 protein coding gene Chr11:84313681-84404433 (-)
129S1/SvImJ ENSMUSG00200047602
 protein coding gene Chr11:81453525-81544065 (-)
A/J ENSMUSG00195041852
 protein coding gene Chr11:81308022-81398566 (-)
AKR/J ENSMUSG00220045608
 protein coding gene Chr11:81522797-81613358 (-)
BALB/cJ ENSMUSG00180038826
 protein coding gene Chr11:81504261-81594942 (-)
C3H/HeJ ENSMUSG00175035948
 protein coding gene Chr11:81454967-81545505 (-)
C57BL/6NJ ENSMUSG00215038275
 protein coding gene Chr11:81087912-81178592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016894
 protein coding gene Chr11:79660508-79751140 (-)
CAST/EiJ ENSTCUG00005043107
 protein coding gene Chr11:81022032-81112451 (-)
CBA/J ENSMUSG00210045345
 protein coding gene Chr11:81272607-81363142 (-)
DBA/2J ENSMUSG00185018311
 protein coding gene Chr11:81604867-81694995 (-)
FVB/NJ ENSMUSG00205039519
 protein coding gene Chr11:81391885-81482566 (-)
JF1/MsJ ENSUMUG00000008235
 protein coding gene Chr11:81926108-82016233 (-)
LP/J ENSMUSG00230026313
 protein coding gene Chr11:82622698-82713229 (-)
NOD/ShiLtJ ENSMUSG00190017608
 protein coding gene Chr11:81604141-81694807 (-)
NZO/HlLtJ ENSMUSG00225039075
 protein coding gene Chr11:84732271-84822903 (-)
PWK/PhJ ENSLUMG00010023099
 protein coding gene Chr11:81427492-81517555 (-)
SPRET/EiJ ENSMSPG00010039732
 protein coding gene Chr11:81891944-81981787 (-)
WSB/EiJ ENSIUOG00005029663
 protein coding gene Chr11:81412639-81503189 (-)



Homology
more
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
  • Synonyms
    BFR2, CHE-1, CHE1, DED
  • Links
    NCBI Gene ID: 26574
    UniProt: Q9NY61

  • Chr Location
    17q12; chr17:36948925-37056874 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous embryos do not develop past the compacted morula stage, and after failing to maintain compaction. Mutant embryos show abnormal morphology at E3.5, with most not forming a blastocoel cavity. Severely reduced cell proliferation is observed before blastocyst formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    209
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018697 Ensembl Gene Model | MGI Sequence Detail 90668 C57BL/6J ±  kb
    transcript ENSMUST00000018841 Ensembl | MGI Sequence Detail 1822 Not Applicable  
    polypeptide ENSMUSP00000018841 Ensembl | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918392, MGI:1923349
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory